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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Perfluorodecalin-soluble fluorescent dyes for the monitoring of circulating nanocapsules with intravital fluorescence microscopy
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Perfluorodecalin-soluble fluorescent dyes for the monitoring of circulating nanocapsules with intravital fluorescence microscopy

机译：全氟萘烷可溶性荧光染料，用于活体荧光显微镜监测循环中的纳米胶囊

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Perfluorodecalin (PFD) is an established artificial oxygen carrier due to its physical capability to solve the respiratory gases oxygen and carbon dioxide. PFD-filled poly(n-butyl-cyanoacrylate) (PACA) nanocapsules are already discussed as effective artificial oxygen carriers, and their principal suitability for intravenous administration had been shown. To further elucidate their action in vivo, it is imperative to characterise their preclinical safety and particularly their biodistribution. For these purposes, intravital fluorescence microscopy would display an attractive technique in order to monitor the PACA nanocapsules in vivo, but unfortunately, it is impossible to stain the PACA nanocapsules with a fluorescent dye fulfilling special criteria required for in vivo microscopy. In order to develop such a dye, a long-chained fluorinated thiol was used to modify a BODIPY derivative that is a highly fluorescent organic compound belonging to the difluoro-boraindacene family, as well as to functionalise mesoscopic systems, such as CdSe/ZnS-quantum dots and gold nanoparticles. Furthermore, a functionalisation of porphyrin derivatives was investigated by placing divalent ions in the centre of these systems. Due to the high solubility of all synthesised dyes in PFD, it should be possible to stain PFD-filled particles in general. However, only the functionalised BODIPY derivative was suitable for in vivo monitoring of the PFD-filled PACA nanocapsules.
机译：全氟萘烷（PFD）由于其解决呼吸气体氧气和二氧化碳的物理能力而成为一种公认的人工氧气载体。已经讨论了填充PFD的聚（氰基丙烯酸正丁酯）（PACA）纳米胶囊作为有效的人造氧载体的作用，并且已经证明了其主要适用于静脉内给药。为了进一步阐明其在体内的作用，必须表征其临床前安全性，尤其是其生物分布。出于这些目的，活体内荧光显微镜将显示出一种吸引人的技术，以便在体内监测PACA纳米胶囊，但不幸的是，不可能用满足体内显微镜所需的特殊标准的荧光染料对PACA纳米胶囊进行染色。为了开发这种染料，长链氟化硫醇用于修饰BODIPY衍生物，该衍生物是属于二氟硼二苯并烯家族的高荧光有机化合物，并用于官能化介观体系，例如CdSe / ZnS-量子点和金纳米粒子。此外，通过将二价离子置于这些系统的中心来研究卟啉衍生物的功能化。由于所有合成染料在PFD中的溶解度很高，因此一般来说，应该可以染满PFD填充的颗粒。但是，只有功能化的BODIPY衍生物适合体内监测PFD填充的PACA纳米胶囊。

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