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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Production of BSA-loaded alginate microcapsules:Influence of spray dryer parameters on the microcapsule characteristics and BSA release
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Production of BSA-loaded alginate microcapsules:Influence of spray dryer parameters on the microcapsule characteristics and BSA release

机译：负载BSA的藻酸盐微胶囊的生产：喷雾干燥器参数对微胶囊特性和BSA释放的影响

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摘要

The aim of this study was to optimize the production of BSA-loaded alginate microcapsules by spray drying and to study the release of bovine serum albumin fraction V(BSA)under gastric simulated conditions.Microcapsule yield,BSA release,microcapsule size and size distribution were characterized following the application of different production parameters including inlet air temperature,inlet air pressure and liquid feed rate.The microcapsules were incubated in 0.1 N HCl and BSA release was quantified over time.The yields were higher with the pressure of 3 bar compared to 4bar and with a feed rate of 0.45 vs.0.2 ml s~(-1).A high feed rate(0.45 vs.0.2 ml s~(-1))allows one to obtain microcapsules with a low BSA release(p=0.0327).The increase of the atomizer inlet temperature leads to microcapsules with a higher BSA release(p=0.0230).A higher air pressure of 4 bar compared to 3 bar resulted in a lower microcapsule size(2.55 vs.2.80 mu m)and led to a narrower size distribution(0.92 vs.1.07).In conclusion,the spray dryer parameters influenced the alginate microcapsule characteristics as well as subsequent protein release into a simulated gastric medium.
机译：这项研究的目的是通过喷雾干燥优化负载BSA的藻酸盐微胶囊的生产，并研究在胃模拟条件下牛血清白蛋白组分V（BSA）的释放。微囊产量，BSA释放，微囊大小和大小分布通过应用不同的生产参数（包括进气温度，进气压力和液体进料速率）对微胶囊进行表征，将微胶囊在0.1 N HCl中温育，并对BSA随时间的释放进行定量分析。在3 bar的压力下，产率高于4 bar进料速率为0.45 vs.0.2 ml s〜（-1）。高进料速率（0.45 vs.0.2 ml s〜（-1））可使人获得低BSA释放的微胶囊（p = 0.0327）雾化器入口温度的升高导致微胶囊的BSA释放量更高（p = 0.0230）.4 bar的气压高于3 bar的气压导致微胶囊的尺寸更小（2.55 vs.80微米）并导致较窄的尺寸分布（0.92比1.07）。总之，喷雾干燥器参数影响藻酸盐微胶囊的特性以及随后的蛋白质释放到模拟胃介质中。

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