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首页> 外文期刊>Journal of nephrology. >Epidemiology of chronic kidney disease in Italy: possible therapeutical approaches.
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Epidemiology of chronic kidney disease in Italy: possible therapeutical approaches.

机译：意大利慢性肾脏病流行病学：可能的治疗方法。

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Chronic kidney disease (CKD) affects a significant percentage of the Italian population, particularly among the elderly. It is estimated that more than 300 patients per million population (pmp) are diagnosed as having CKD each year, and about 0.8% of Italians are thought to have serum creatinine levels >=1.5 mg/dL. The number of patients being admitted to renal replacement therapies (RRT) has been growing up rapidly in the last decades, leading to 134 patients pmp starting RRT throughout 2000 and to 804 patients pmp on chronic RRT in the same year. As such therapies are very expensive, CKD must be therefore considered as a striking problem also by a socio-economical point of view. As a consequence, any medical intervention being able to halt or at least to slow down the progression of CKD and/or to prevent the development of related complications or comorbidities is of paramount importance. Several therapeutical interventions, including hypertension and proteinuria control, protein restriction, anemia,calcium-phosphate disorders and dyslipidemia correction and smoking cessation, showed to be actually effective in at least partially achieving these objectives. Other emerging therapeutical approaches, although well promising, need further evidence to be definitively included in the management of CKD patients. Particular efforts should be made in order to refer these patients to the nephrologist as early as possible, as it has been widely demonstrated that an early and regular nephrological care leads to decreased morbidity and mortality and also to decreased social costs.
机译：慢性肾脏病（CKD）影响了很大一部分意大利人口，尤其是老年人。据估计，每年每百万人口中有300多例患者被诊断患有CKD，据认为约0.8％的意大利人血清肌酐水平> = 1.5 mg / dL。在过去的几十年中，接受肾脏替代疗法（RRT）的患者数量一直在迅速增长，导致2000年有134名患者开始使用RRT，同年有804名患者接受了慢性RRT。由于这种疗法非常昂贵，因此从社会经济的观点出发，必须将CKD视为一个突出的问题。因此，任何能够阻止或至少减慢CKD进程和/或防止相关并发症或合并症发展的医学干预措施都是至关重要的。几种治疗干预措施，包括高血压和蛋白尿控制，蛋白质限制，贫血，磷酸钙紊乱，血脂异常纠正和戒烟，在至少部分实现这些目标方面实际上是有效的。其他新兴的治疗方法尽管前景很好，但仍需要进一步的证据明确地纳入CKD患者的治疗。为了尽早将这些患者转诊至肾脏病专家，应做出特别的努力，因为已广泛证明早期和定期的肾脏病治疗可降低发病率和死亡率，并降低社会成本。

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