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首页> 外文期刊>Journal of Micromechanics and Microengineering >The NeuroMedicator - a micropump integrated with silicon microprobes for drug delivery in neural research
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The NeuroMedicator - a micropump integrated with silicon microprobes for drug delivery in neural research

机译：NeuroMedicator-与硅微探针集成的微泵，用于神经研究中的药物输送

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The NeuroMedicator is a micropump integrated with application-specific silicon microprobes aimed for drug delivery in neural research with small animals. The micropump has outer dimensions of 11 × 15 × 3 mm~3 and contains 16 reservoirs each having a capacity of 0.25 μL. Thereby, the reservoirs are interconnected in a pearl-chain-like manner and are connected to two 8 mm long silicon microprobes. Each microprobe has a cross-sectional area of 250 × 250 μm~2 and features an integrated drug delivery channel of 50 × 50 μm~2 with an outlet of 25 μm in diameter. The drug is loaded to the micropump prior to implantation. After implantation, individual 0.25 μL portions of drug can be sequentially released by short heating pulses applied to a polydimethylsiloxane (PDMS) layer containing Expancel microspheres. Due to local, irreversible thermal expansion of the elastic composite material, the drug is displaced from the reservoirs and released through the microprobe outlet directly to the neural tissue. While implanted, leakage of drug by diffusion occurs due to the open microprobe outlets. The maximum leakage within the first three days after implantation is calculated to be equivalent to 0.06 μL of drug solution.
机译：NeuroMedicator是与专用硅微探针集成的微型泵，旨在在小动物的神经研究中进行药物输送。微型泵的外部尺寸为11×15×3 mm〜3，包含16个容量为0.25μL的容器。因此，储层以类似珍珠链的方式互连，并连接到两个8毫米长的硅微探针。每个微探针的横截面积为250×250μm〜2，并具有5​​0×50μm〜2的集成药物输送通道，并具有直径为25μm的出口。在植入之前，将药物加载到微型泵中。植入后，可通过向包含Expancel微球的聚二甲基硅氧烷（PDMS）层施加短加热脉冲，依次释放0.25μL的药物。由于弹性复合材料的局部不可逆的热膨胀，药物从储层中移位并通过微探针出口直接释放到神经组织。植入时，由于开放的微探针出口，药物通过扩散发生泄漏。植入后前三天内的最大泄漏量经计算等于0.06μL药物溶液。

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