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首页> 外文期刊>Journal of Neurophysiology >Spinobulbar neurons in lamprey: cellular properties and synaptic interactions.
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Spinobulbar neurons in lamprey: cellular properties and synaptic interactions.

机译：七lamp鳗的脊髓小球神经元：细胞特性和突触相互作用。

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摘要

An in vitro preparation of the nervous system of the lamprey, a lower vertebrate, was used to characterize the properties of spinal neurons with axons projecting to the brain stem [i.e., spinobulbar (SB) neurons)]. To identify SB neurons, extracellular electrodes on each side of the spinal cord near the obex recorded the axonal spikes of neurons impaled with sharp intracellular microelectrodes in the rostral spinal cord. The ascending spinal neurons (n = 144) included those with ipsilateral (iSB) (63/144), contralateral (cSB) (77/144), or bilateral (bSB) (4/144) axonal projections to the brain stem. Intracellular injection of biocytin revealed that the SB neurons had small- to medium-size somata and most had dendrites confined to the ipsilateral side of the cord, although about half of the cSB neurons also had contralateral dendrites. Most SB neurons had multiple axonal branches including descending axons. Electrophysiologically, the SB neurons were similar to other lamprey spinal neurons, firing spikes throughout long depolarizing pulses with some spike-frequency adaptation. Paired intracellular recordings between SB and reticulospinal (RS) neurons revealed that SB neurons made either excitatory or inhibitory synapses on RS neurons and the SB neurons received excitatory input from RS neurons. Mutual excitation and feedback inhibition between pairs of RS and SB neurons were observed. The SB neurons also received excitatory inputs from primary mechanosensory neurons (dorsal cells), and these same SB neurons were rhythmically active during fictive swimming, indicating that SB neurons convey both sensory and locomotor network information to the brain stem.
机译：七rey鳗（一种下部脊椎动物）的神经系统的体外制备用于表征脊柱神经元的特性，其中轴突伸向脑干[即，脊髓小球（SB）神经元]。为了识别SB神经元，在靠近肥胖者的脊髓每一侧的细胞外电极记录了神经元的轴突突刺，这些神经突刺刺入了喙状脊髓中的尖锐的细胞内微电极。上升的脊髓神经元（n = 144）包括对脑干具有同侧（iSB）（63/144），对侧（cSB）（77/144）或双侧（bSB）（4/144）轴突的神经元。胞内注射生物素表明，SB神经元具有中小尺寸的躯体，大多数树突均局限于脐带同侧，尽管大约一半的cSB神经元也具有对侧树突。大多数SB神经元具有多个轴突分支，包括下降的轴突。在电生理上，SB神经元与其他七lamp鳗脊神经元相似，在长去极化脉冲的整个过程中会发射出尖峰，并具有一定的尖峰频率适应性。 SB和网状脊髓（RS）神经元之间的配对细胞内记录显示，SB神经元对RS神经元产生了兴奋性或抑制性突触，并且SB神经元收到了来自RS神经元的兴奋性输入。观察到成对的RS和SB神经元之间相互激励和反馈抑制。 SB神经元还从原代机械感觉神经元（背侧细胞）收到兴奋性输入，这些相同的SB神经元在虚构游泳中具有节律性活动，表明SB神经元将感觉和运动网络信息传递到脑干。

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