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首页> 外文期刊>Journal of Neurophysiology >Contribution of vestibular commissural pathways to spatial orientation of the angular vestibuloocular reflex.
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Contribution of vestibular commissural pathways to spatial orientation of the angular vestibuloocular reflex.

机译：前庭连合通路对角前庭反射的空间方向的贡献。

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摘要

During nystagmus induced by the angular vestibuloocular reflex (aVOR), the axis of eye velocity tends to align with the direction of gravito-inertial acceleration (GIA), a process we term "spatial orientation of the aVOR." We studied spatial orientation of the aVOR in rhesus and cynomolgus monkeys before and after midline section of the rostral medulla abolished all oculomotor functions related to velocity storage, leaving the direct optokinetic and vestibular pathways intact. Optokinetic afternystagmus and the bias component of off-vertical-axis rotation were lost, and the aVOR time constant was reduced to a value commensurate with the time constants of primary semicircular canal afferents. Spatial orientation of the aVOR, induced either during optokinetic or vestibular stimulation, was also lost. Vertical and roll aVOR time constants could no longer be lengthened in side-down or supine/prone positions, and static and dynamic tilts of the GIA no longer produced cross-coupling from the yaw to pitch andyaw to roll axes. Consequently, the induced nystagmus remained entirely in head coordinates after the lesion, regardless of the direction of the resultant GIA vector. Gains of the aVOR and of optokinetic nystagmus to steps of velocity were unaffected or slightly increased. These results are consistent with a model in which the direct aVOR pathways are organized in semicircular canal coordinates and spatial orientation is restricted to the indirect (velocity storage) pathways.
机译：在角膜前庭反射（aVOR）引起的眼球震颤期间，眼球速度轴倾向于与重力-惯性加速度（GIA）方向对齐，这一过程我们称为“ aVOR的空间方向”。我们研究了在延髓延髓中线段之前和之后的恒河猴和食蟹猕猴的aVOR的空间定位，取消了所有与速度存储有关的动眼功能，使直接的光动力和前庭通路保持完整。失去了视动觉性眼震和偏轴旋转的偏向分量，并且将aVOR时间常数减小到与初级半圆形管传入的时间常数相对应的值。在视动或前庭刺激过程中诱导的aVOR的空间方向也丢失了。垂直和侧倾aVOR时间常数不再可以在侧面朝下或仰卧/俯卧位置上加长，而且GIA的静态和动态倾斜不再产生从偏航到俯仰和偏航到横滚轴的交叉耦合。因此，无论所得GIA载体的方向如何，诱发的眼球震颤都完全留在病变后的头部坐标中。 aVOR和视动性眼球震颤对速度步幅的增加未受影响或略有增加。这些结果与模型相吻合，在模型中，直接aVOR通路组织在半圆形管座坐标系中，空间方向仅限于间接（速度存储）通路。

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