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首页> 外文期刊>Journal of Neurophysiology >Synchronization of neuronal activity in the human primary motor cortex by transcranial magnetic stimulation: an EEG study.
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Synchronization of neuronal activity in the human primary motor cortex by transcranial magnetic stimulation: an EEG study.

机译：经颅磁刺激同步人类初级运动皮层神经元活动：一项脑电图研究。

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Using multichannel electroencephalography (EEG), we investigated temporal dynamics of the cortical response to transcranial magnetic stimulation (TMS). TMS was applied over the left primary motor cortex (M1) of healthy volunteers, intermixing single suprathreshold pulses with pairs of sub- and suprathreshold pulses and simultaneously recording EEG from 60 scalp electrodes. Averaging of EEG data time locked to the onset of TMS pulses yielded a waveform consisting of a positive peak (30 ms after the pulse P30), followed by two negative peaks [at 45 (N45) and 100 ms]. Peak-to-peak amplitude of the P30-N45 waveform was high, ranging from 12 to 70 microV; in most subjects, the N45 potential could be identified in single EEG traces. Spectral analysis revealed that single-pulse TMS induced a brief period of synchronized activity in the beta range (15-30 Hz) in the vicinity of the stimulation site; again, this oscillatory response was apparent not only in the EEG averages but also in single traces. Both the N45 and the oscillatory response were lower in amplitude in the 12-ms (but not 3-ms) paired-pulse trials, compared with the single-pulse trials. These findings are consistent with the possibility that TMS applied to M1 induces transient synchronization of spontaneous activity of cortical neurons within the 15- to 30-Hz frequency range. As such, they corroborate previous studies of cortical oscillations in the motor cortex and point to the potential of the combined TMS/EEG approach for further investigations of cortical rhythms in the human brain.
机译：使用多通道脑电图（EEG），我们调查了皮质对经颅磁刺激（TMS）反应的时间动态。将TMS应用于健康志愿者的左初级运动皮层（M1），将单个阈上脉冲与成对的亚阈下和阈上脉冲混合，并同时记录60个头皮电极的EEG。锁定到TMS脉冲开始的EEG数据时间的平均值产生了一个波形，该波形由一个正峰（在脉冲P30之后30 ms）和两个负峰[在45（N45）和100 ms]组成。 P30-N45波形的峰峰幅度很高，范围为12至70 microV。在大多数受试者中，可以在单个EEG迹线中识别出N45电位。频谱分析显示，单脉冲TMS在刺激部位附近的β范围（15-30 Hz）内引起了短暂的同步活动;同样，这种振荡响应不仅在EEG平均数中而且在单迹线中也很明显。与单脉冲试验相比，在12毫秒（但不是3毫秒）的成对脉冲试验中，N45和振荡响应的幅度均较低。这些发现与应用于M1的TMS诱导15至30 Hz频率范围内的皮质神经元自发活动的瞬时同步的可能性一致。因此，他们证实了运动皮层皮质振荡的先前研究，并指出了结合TMS / EEG方法进行人脑皮质节律研究的潜力。

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