...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroscience Methods >Simultaneous telemetric monitoring of tail-skin and core body temperature in a rat model of thermoregulatory dysfunction.
【24h】

Simultaneous telemetric monitoring of tail-skin and core body temperature in a rat model of thermoregulatory dysfunction.

机译：同时遥测温度调节功能障碍大鼠模型中的尾巴皮肤和核心体温。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Temperature dysfunction, clinically described as hot flashes/flushes and night sweats, commonly occur in women transitioning through menopause. Research in this field has yet to fully elucidate the biological underpinnings explaining this dysfunction. The need to develop animal models that can be used to study hormone-dependent temperature regulation is essential to advancing this scientific area. Development of telemetric transmitters for monitoring tail-skin (TST) and core body (CBT) temperatures for animal research has increased the accuracy of data by reducing extraneous factors associated with previous methods. However, until recently, TST and CBT could not be simultaneously measured telemetrically within the same animal. In this report, new dual temperature monitoring transmitters were validated by simultaneously evaluating them with the single measurement transmitters using the ovariectomized (OVX) rat thermoregulatory dysfunction model. A major advantage of measuring TST and CBT in the same animal is the ability to relate temporal changes on these two temperature parameters. Comparative experimentation was performed by single administration of clonidine (alpha(2) adrenergic agonist), MDL-100907 (5-HT(2a) antagonist), or a 7-day treatment of 17alpha-ethinyl estradiol (EE). Clonidine caused decreases in TST and CBT, MDL-100907 caused increases in TST while decreasing CBT, and EE caused decreases in TST with minor CBT decreases only at the higher dose. Data from either probe type showed similar results on temperature parameters regardless of transmitter used. These findings support the use of the new dual temperature transmitters and should enhance the quality and interpretation of data being generated in thermoregulation studies.
机译：温度功能障碍，临床上描述为潮热/潮红和盗汗，通常发生在绝经期的女性中。该领域的研究尚未完全阐明解释这种功能障碍的生物学基础。开发可用于研究激素依赖性温度调节的动物模型对于推进这一科学领域至关重要。用于动物研究的监测尾皮（TST）和核心体（CBT）温度的遥测变送器的开发通过减少与先前方法相关的外部因素，提高了数据的准确性。但是，直到最近，在同一只动物中还无法同时遥测TST和CBT。在本报告中，使用去卵巢（OVX）大鼠体温调节功能障碍模型与单测量变送器同时评估它们，从而验证了新的双温度监测变送器。在同一只动物中测量TST和CBT的主要优点是能够将这两个温度参数的时间变化关联起来。通过单次施用可乐定（α（2）肾上腺素能激动剂），MDL-100907（5-HT（2a）拮抗剂）或进行17天的17α-乙炔基雌二醇（EE）治疗，进行比较实验。可乐定导致TST和CBT降低，MDL-100907导致TST升高，而CBT降低，而EE导致TST降低，仅在较高剂量下CBT降低。无论使用哪种变送器，两种探头类型的数据在温度参数上都显示出相似的结果。这些发现支持新型双温度变送器的使用，并应提高温度调节研究中生成的数据的质量和解释。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号