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首页> 外文期刊>Journal of Neuroscience Methods >Estimating the duration of intracellular action potentials in muscle fibres from single-fibre extracellular potentials.
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Estimating the duration of intracellular action potentials in muscle fibres from single-fibre extracellular potentials.

机译：从单纤维细胞外电位估算肌纤维中细胞内动作电位的持续时间。

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摘要

In situ recording of the intracellular action potential (IAP) of human muscle fibres is not yet possible, and consequently, knowledge concerning certain IAP characteristics is still limited. According to the core-conductor theory, close to a fibre, a single fibre action potential (SFAP) can be assumed to be proportional to the IAP second derivative. Thus, we might expect to be able to derive some characteristics of the IAP, such as the duration of its spike, from the SFAP waveform. However, SFAP properties not only depend on the IAP shape but also on the fibre-to-electrode (radial) distance and other physiological properties of the fibre. In this paper we, first, propose an SFAP parameter (the negative phase duration, NPD) appropriate for estimating the IAP spike duration and, second, show that this parameter is largely independent of changes in radial distance and muscle fibre propagation velocity. Estimation of the IAP spike duration from a direct measurement taken from the SFAP waveform provides a possible way to enhance the accuracy of SFAP models. Because IAP spike duration is known to be sensitive to the effects of fatigue and calcium accumulation, the proposed SFAP parameter, the NPD, has potential value in electrodiagnosis and as an indicator of IAP profile changes due to peripheral fatigue.
机译：尚不可能原位记录人肌肉纤维的细胞内动作电位（IAP），因此，有关某些IAP特性的知识仍然有限。根据芯导体理论，接近纤维时，单纤维动作电位（SFAP）可以假定与IAP二阶导数成比例。因此，我们可能希望能够从SFAP波形中得出IAP的某些特性，例如其尖峰持续时间。但是，SFAP特性不仅取决于IAP形状，还取决于纤维到电极（径向）的距离以及其他纤维的生理特性。在本文中，我们首先提出适合于估计IAP尖峰持续时间的SFAP参数（负相持续时间，NPD），其次，表明该参数在很大程度上与径向距离和肌纤维传播速度的变化无关。通过从SFAP波形中直接进行测量来估计IAP尖峰持续时间，为提高SFAP模型的准确性提供了一种可能的方法。因为已知IAP峰值持续时间对疲劳和钙积累的影响敏感，所以建议的SFAP参数NPD在电诊断中具有潜在价值，并且可以作为由于外周疲劳而导致IAP轮廓变化的指标。

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