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首页> 外文期刊>Journal of Neuroscience Methods >Intermittent convection-enhanced delivery to the brain through a novel transcutaneous bone-anchored port
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Intermittent convection-enhanced delivery to the brain through a novel transcutaneous bone-anchored port

机译：通过新型经皮骨锚定端口间歇性对流增强向大脑的输送

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Convection-enhanced delivery (CED) describes a novel method of drug delivery to the brain through intraparenchymal microcatheters. One of the barriers to effective translation of CED to clinical trials is the requirement for intermittent delivery over prolonged periods. This is particularly relevant for delivery of neurotrophins for the treatment of Parkinson's disease where chronic infusion of glial cell-line derived neurotrophic factor (GDNF) with subcutaneously implanted pumps has been associated with poor distribution and local toxicity due to point source accumulation. We have previously described the development of an implantable catheter for CED which facilitates repeated drug administrations at intervals of up to one month. The aim of this study was to determine the feasibility of implanting a transcutaneous bone-anchored port (TBAP) which facilitates chronic intermittent drug delivery to the brain. We describe the design and development of a titanium port which was implanted in Large White and NIH miniature pigs for periods of up to three months. By intermittently accessing the port with a needle administration set it was possible to repeatedly perform CED infusions at one month intervals. This study confirms the safety and feasibility of performing intermittent CED through a transcutaneous bone-anchored port. The use of a transcutaneous port has the potential to facilitate clinical translation of CED of therapeutics requiring intermittent delivery to achieve optimum efficacy whilst negating the need for subcutaneously implanted pumps. ? 2013 Elsevier B.V.
机译：对流增强输送（CED）描述了通过实质内微导管将药物输送到大脑的新方法。有效地将CED转换为临床试验的障碍之一是需要长时间间歇性给药。这与神经营养素的治疗帕金森氏病的治疗特别相关，在该疾病中，皮下植入泵向神经胶质细胞系衍生的神经营养因子（GDNF）的长期输注与不良的分布和由于点源积累引起的局部毒性有关。先前我们已经描述了用于CED的可植入导管的开发，该导管便于以长达一个月的间隔重复给药。这项研究的目的是确定植入经皮骨锚固端口（TBAP）的可行性，该端口有助于将慢性间歇性药物输送到大脑。我们描述了钛端口的设计和开发，该端口已植入大型白猪和NIH小型猪，长达三个月。通过用针头给药装置间歇性地进入端口，可以以一个月的间隔重复进行CED输注。这项研究证实了通过经皮骨锚定端口进行间歇性CED的安全性和可行性。透皮端口的使用有可能促进需要间歇递送以达到最佳功效同时消除对皮下植入泵的需要的治疗剂的CED的临床翻译。 ？ 2013年Elsevier B.V.

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