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The impact of medications on quality of life in attention-deficit hyperactivity disorder: a systematic review.

机译：注意缺陷多动障碍中药物对生活质量的影响：系统评价。

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Quality of life (QOL) describes an individual's subjective perception of their position in life as evidenced by their physical, psychological and social functioning. Although an established outcome measure in physical health, QOL has more recently become an increasingly important measure in mental health clinical work and research. This article reviews the evidence describing the impact of medications on QOL in attention-deficit hyperactivity disorder (ADHD). Databases were searched for research studies describing the effects of medication on QOL in ADHD: 25 relevant studies were identified. Most (n = 20) of these studies have focused on children and adolescents, and most have investigated a single molecule, atomoxetine (n = 15), with relatively few studies investigating methylphenidate (n = 5), amfetamines (n = 4) and manifaxine (n = 1). These studies support a positive short-term effect of medication on QOL in ADHD for children, adolescents and adults that mirrors, to some extent, the effects of these medications on ADHD symptoms, although with smaller effect sizes. Notwithstanding measurement issues, it will continue to be important that those designing and conducting clinical trials in ADHD, including both pharmacological and non-pharmacological treatments, continue to include measures of QOL as secondary outcome measures. In particular, information about QOL effects in adults and in subjects of all ages taking methylphenidate and amfetamine treatments is urgently needed. The lack of systematic studies of the impact on QOL of psychological therapies, either on their own or in multimodal combinations with medication, is a serious omission that should be urgently addressed.
机译：生活质量（QOL）描述了个人对自己在生活中的地位的主观感知，这由其身体，心理和社会功能证明。尽管在身体健康方面已经建立了既定的结果指标，但生活质量已成为心理健康临床工作和研究中越来越重要的指标。本文回顾了描述药物对注意缺陷多动障碍（ADHD）中生活质量的影响的证据。在数据库中搜索描述药物对多动症生活质量的影响的研究：已鉴定出25项相关研究。这些研究中的大多数（n = 20）集中于儿童和青少年，并且大多数研究了一种单分子的阿托西汀（n = 15），很少有研究研究哌醋甲酯（n = 5），安非他明（n = 4）和manifaxine（n = 1）。这些研究支持药物对儿童，青少年和成人的ADHD的QOL有积极的短期影响，尽管影响量较小，但在一定程度上反映了这些药物对ADHD症状的影响。尽管存在测量问题，但在ADHD中设计和进行ADHD临床试验（包括药物治疗和非药物治疗）的人员继续将QOL措施作为次要结局措施，这一点仍然至关重要。尤其是，迫切需要有关成年人和所有接受哌醋甲酯和安非他明治疗的各个年龄段受试者的QOL效应的信息。缺乏对心理疗法对生活质量的影响的系统研究，无论是单独使用还是与药物联用，都是一个严重的遗漏，应立即解决。

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  • 来源
    《CNS drugs》 |2010年第10期|共24页
  • 作者

    Coghill D;

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  • 正文语种 eng
  • 中图分类 药学;
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