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首页> 外文期刊>Journal of opioid management >Loss of antinociceptive effectiveness of morphine and oxycodone following titration of levothyroxine: Case reports and a brief review of published literature
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Loss of antinociceptive effectiveness of morphine and oxycodone following titration of levothyroxine: Case reports and a brief review of published literature

机译:左甲状腺素滴定后吗啡和羟考酮的止痛作用丧失:病例报告和已发表文献的简要回顾

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摘要

Chronic pain management is a complex process involving numerous facets of care. Although pharmacotherapy is apart of the treatment plan for these patients, it often represents the most complex of the modalities to manage. Two chronic pain patients with loss of pain control following dosage increase in levothyroxine supplementation are presented. The authors sought to identify relationships among thyroid status, opioid pharmacokinetics, and nociceptive processing. In conclusion, well-designed human studies using pain models and controlling for thyroid status are warranted to better understand the impact this system has on pain control.
机译:慢性疼痛管理是一个复杂的过程,涉及许多方面的护理。尽管药物治疗是这些患者的治疗计划的一部分,但它通常代表最复杂的管理方式。介绍了两名慢性疼痛患者,在增加左甲状腺素剂量后,疼痛控制消失。作者试图确定甲状腺状态,阿片类药物动力学和伤害性加工之间的关系。总之,使用疼痛模型和控制甲状腺状态进行精心设计的人体研究有必要更好地了解该系统对疼痛控制的影响。

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