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Epigenomic approach in understanding Alzheimer's disease and type 2 diabetes mellitus.

机译：认识阿尔茨海默氏病和2型糖尿病的表观基因组方法。

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摘要

Cognitive decline is a debilitating feature of Alzheimer's disease (AD). The causes leading to such impairment are still poorly understood and effective treatments for AD are still unavailable. Type 2 diabetes mellitus (T2DM) has been identified as a risk factor for AD due to desensitisation of insulin receptors in the brain. Recent studies have suggested that epigenetic mechanisms may also play a pivotal role in the pathogenesis of both AD and T2DM. This article describes the correlation between AD and T2DM and provides the insights to the epigenetics of AD. Currently, more research is needed to clarify the exact role of epigenetic regulation in the course and development of AD and also in relation to insulin. Research conducted especially in the earlier stages of the disease could provide more insight into its underlying pathophysiology to help in early diagnosis and the development of more effective treatment strategies.
机译：认知能力下降是阿尔茨海默氏病（AD）的衰弱特征。导致这种损害的原因仍知之甚少，仍然缺乏有效的AD治疗方法。由于大脑中胰岛素受体的脱敏性，2型糖尿病（T2DM）已被确定为AD的危险因素。最近的研究表明，表观遗传机制也可能在AD和T2DM的发病机理中起关键作用。本文介绍了AD与T2DM之间的相关性，并为AD的表观遗传学提供了见解。当前，需要更多的研究来阐明表观遗传调控在AD的过程和发展中以及与胰岛素有关的确切作用。特别是在疾病的早期阶段进行的研究可以提供对其潜在病理生理的更多了解，以帮助早期诊断和制定更有效的治疗策略。

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