首页> 外文期刊>Journal of Nutritional Science and Vitaminology >The effect of dietary fatty acid manipulation on phagocytic activity and cytokine production by peritoneal cells from Balb/c mice.
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The effect of dietary fatty acid manipulation on phagocytic activity and cytokine production by peritoneal cells from Balb/c mice.

机译:饮食中的脂肪酸操作对Balb / c小鼠腹膜细胞吞噬活性和细胞因子产生的影响。

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Previous studies have demonstrated that dietary lipid manipulation may modify immune response by affecting lymphocyte proliferation, phagocytosis, cytokine production, etc. In this paper, we investigated the effect of olive oil (OO) on the phagocytic activity and cytokine production by murine peritoneal cells. These results were compared with those obtained from mice fed diets containing sunflower oil (SO) or hydrogenated coconut oil (HCO). Balb/c mice were divided into three groups and fed diets containing 15% by weight of either OO, SO or HCO for 5, 15, 30, 60 or 90 d. Phagocytic activity and interleukin-1 (IL-1) production were increased in OO-fed mice as compared to the other groups. On the contrary, no significant differences were observed in the levels of tumor necrosis factor (TNF) production, although the levels of this cytokine were slightly increased in mice fed the OO diet. These observations suggest that OO is able to modify the immune response and therefore, it may be used as an immunomodulatory agent.
机译:先前的研究表明,饮食脂质操作可通过影响淋巴细胞增殖,吞噬作用,细胞因子产生等来改变免疫反应。在本文中,我们研究了橄榄油(OO)对鼠腹膜细胞吞噬活性和细胞因子产生的影响。将这些结果与从饲喂含葵花籽油(SO)或氢化椰子油(HCO)的日粮的小鼠中获得的结果进行了比较。将Balb / c小鼠分成三组,并喂食含有15重量%的OO,SO或HCO的饮食5、15、30、60或90天。与其他组相比,OO喂养的小鼠的吞噬活性和白介素-1(IL-1)的产生增加。相反,尽管在喂OO饮食的小鼠中该细胞因子的水平略有增加,但在肿瘤坏死因子(TNF)产生水平上没有观察到显着差异。这些观察结果表明OO能够改变免疫应答,因此可以用作免疫调节剂。

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