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首页> 外文期刊>Journal of Nutritional Science and Vitaminology >Cholesterol lowering effect of sulfur-containing amino acids added to a soybean protein diet in rats.
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Cholesterol lowering effect of sulfur-containing amino acids added to a soybean protein diet in rats.

机译：添加到大鼠大豆蛋白饮食中的含硫氨基酸降低胆固醇的作用。

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摘要

The cholesterol-lowering action of soybean protein was studied with rats from the aspect of sulfur-containing amino acids using casein as a counterpart. Weanling rats were fed for 3 wk on a soybean protein isolate (SPI) or casein diet. Serum cholesterol levels did not differ between the two diet groups, but were lowered by supplementing methionine to a 10% SPI diet or cystine to an amino acid mixture diet, equivalent to a 10% SPI or to a 20% SPI diet. By adding methionine or cystine to a 10% SPI diet, cholesterol 7alpha-hydroxylase activity was elevated concomitantly with elevated hepatic glutathione (GSH) level, while hydroxyl methyl-glutalyl coenzyme A reductase activity was reduced by methionine, regardless of GSH levels. Excretion of fecal steroid was not significantly changed by addition of either amino acid, as expressed per body weight. These results indicate that the relative amount of methionine and cystine in a diet affected cholesterol metabolizing enzyme activity in a way not parallel to GSH concentration.
机译：从大鼠的含硫氨基酸出发，以酪蛋白为辅料研究了大豆蛋白的降胆固醇作用。给断奶的大鼠喂大豆蛋白分离物（SPI）或酪蛋白饮食3周。两组饮食之间的血清胆固醇水平没有差异，但是通过在10％SPI饮食中补充蛋氨酸或在氨基酸混合饮食（相当于10％SPI或20％SPI饮食）中补充胱氨酸来降低血清胆固醇水平。通过在10％的SPI饮食中添加蛋氨酸或胱氨酸，胆固醇7α-羟化酶活性与肝谷胱甘肽（GSH）水平升高同时升高，而羟甲基-戊二酰辅酶A还原酶活性被蛋氨酸降低，而与GSH水平无关。粪便类固醇的排泄没有增加任何氨基酸，以每体重表示。这些结果表明，饮食中蛋氨酸和胱氨酸的相对含量以与GSH浓度不平行的方式影响胆固醇代谢酶的活性。

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