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首页> 外文期刊>Journal of Nutritional Science and Vitaminology >Meta-analysis: Low-dose intake of vitamin e combined with other vitamins or minerals may decrease all-cause mortality
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Meta-analysis: Low-dose intake of vitamin e combined with other vitamins or minerals may decrease all-cause mortality

机译：荟萃分析：低剂量摄入维生素e与其他维生素或矿物质结合可能会降低全因死亡率

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It has been suggested that vitamin E alone or combined with other vitamins or minerals can prevent oxidative stress and slow oxidative injury-related diseases, such as cardiovascular disease and cancer. A comprehensive search of PubMed/MEDLINE, EMBASE and the Cochrane Library was performed. Relative risk was used as an effect measure to compare the intervention and control groups. A total of 33 trials were included in the metaanalysis. Neither vitamin E intake alone (RR51.01; 95% CI, 0.97 to 1.04; p50.77) nor vitamin E intake combined with other agents (RR50.97; 95% CI, 0.89 to 1.06; p50.55) was correlated with all-cause mortality. Subgroup analyses revealed that low-dose vitamin E supplementation combined with other agents is associated with a statistically significant reduction in all-cause mortality (RR50.92; 95% CI, 0.86 to 0.98; p50.01), and vitamin E intake combined with other agents is associated with a statistically significant reduction in mortality rates among individuals without probable or confirmed diseases (RR50.92; 95% CI, 0.86 to 0.99; p50.02). Neither vitamin E intake alone nor combined with other agents is associated with a reduction in all-cause mortality. But a low dose (,400 IU/d) of vitamin E combined with other agents is correlated with a reduction in all-cause mortality, and vitamin E intake combined with other agents is correlated with a reduction in the mortality rate among individuals without probable or confirmed diseases.
机译：有人提出，单独使用维生素E或与其他维生素或矿物质组合使用维生素E可以预防氧化应激并减缓与氧化损伤有关的疾病，例如心血管疾病和癌症。对PubMed / MEDLINE，EMBASE和Cochrane库进行了全面搜索。相对危险度用作比较干预组和对照组的一种效果度量。荟萃分析共纳入33个试验。单独摄入维生素E（RR51.01; 95％CI，0.97至1.04; p50.77）或维生素E与其他药物联合摄入（RR50.97; 95％CI，0.89至1.06; p50.55）均与摄入量无关全因死亡率。亚组分析显示，低剂量补充维生素E与其他药物合用可导致全因死亡率的统计学显着降低（RR50.92; 95％CI，0.86至0.98; p50.01），以及维生素E的摄入与在没有可能或尚未确诊疾病的个体中，其他药物与死亡率的统计显着降低相关（RR50.92; 95％CI，0.86至0.99; p50.02）。单独摄入维生素E或与其他药物合用均不会降低全因死亡率。但是，低剂量（400 IU / d）的维生素E与其他药物合用会导致全因死亡率的降低，而维生素E的摄入与其他药物合用会降低个体之间的死亡率，这可能与或已确诊的疾病。

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