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首页> 外文期刊>Journal of neurology >Predictors of progression of cognitive decline in Alzheimer's disease: the role of vascular and sociodemographic factors.
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Predictors of progression of cognitive decline in Alzheimer's disease: the role of vascular and sociodemographic factors.

机译：阿尔茨海默氏病认知衰退进展的预测因子：血管和社会人口统计学因素的作用。

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Rates of disease progression differ among patients with Alzheimer's disease, but little is known about prognostic predictors. The aim of the study was to assess whether sociodemographic factors, disease severity and duration, and vascular factors are prognostic predictors of cognitive decline in Alzheimer's disease progression. We conducted a longitudinal clinical study in a specialized clinical unit for the diagnosis and treatment of dementia in Rome, Italy. A total of 154 persons with mild to moderate Alzheimer's disease consecutively admitted to the dementia unit were included. All patients underwent extensive clinical examination by a physician at admittance and all follow-ups. We evaluated the time-dependent probability of a worsening in cognitive performance corresponding to a 5-point decrease in Mini-Mental State Examination (MMSE) score. Survival analysis was used to analyze risk of faster disease progression in relation to age, education, severity and duration of the disease, family history of dementia, hypertension, hypercholesterolemia, and type 2 diabetes. Younger and more educated persons were more likely to have faster Alzheimer's disease progression. Vascular factors such as hypertension and hypercholesterolemia were not found to be significantly associated with disease progression. However, patients with diabetes had a 65% reduced risk of fast cognitive decline compared to Alzheimer patients without diabetes. Sociodemographic factors and diabetes predict disease progression in Alzheimer's disease. Our findings suggest a slower disease progression in Alzheimer's patients with diabetes. If confirmed, this result will contribute new insights into Alzheimer's disease pathogenesis and lead to relevant suggestions for disease treatment.
机译：阿尔茨海默氏病患者的疾病进展速度各不相同，但对预后指标知之甚少。该研究的目的是评估社会人口统计学因素，疾病严重程度和持续时间以及血管因素是否是阿尔茨海默氏病进展中认知能力下降的预后指标。我们在意大利罗马的一个专门的临床部门进行了纵向临床研究，以诊断和治疗痴呆症。总共纳入了154名先后被纳入痴呆症病房的轻度至中度阿尔茨海默氏病患者。所有患者在入院和所有随访过程中均接受医生的广泛临床检查。我们评估了与小心理状态考试（MMSE）得分降低5分相对应的认知能力恶化的时间依赖性概率。生存分析用于分析与年龄，教育程度，疾病严重程度和持续时间，痴呆症家族史，高血压，高胆固醇血症和2型糖尿病相关的疾病进展加快的风险。年轻人和受过良好教育的人更可能患有更快的阿尔茨海默氏病进展。未发现诸如高血压和高胆固醇血症等血管因素与疾病进展显着相关。但是，与没有糖尿病的阿尔茨海默病患者相比，糖尿病患者的快速认知下降风险降低了65％。社会人口统计学因素和糖尿病可以预测阿尔茨海默氏病的进展。我们的发现表明，阿尔茨海默氏症糖尿病患者的疾病进展较慢。如果得到证实，该结果将为阿尔茨海默氏病的发病机理提供新的见解，并为疾病治疗提供相关建议。

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