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首页> 外文期刊>Journal of orthopaedic research >Bisphosphonate-induced reductions in rat femoral bone energy absorption and toughness are testing rate-dependent
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Bisphosphonate-induced reductions in rat femoral bone energy absorption and toughness are testing rate-dependent

机译：双膦酸盐诱导的大鼠股骨骨吸收和韧性降低与速率相关

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Bisphosphonates have been used for years to suppress bone turnover and reduce fracture risk. Bisphosphonates have recently been associated with atypical femoral fractures, which are catastrophic, low trauma, brittle fractures that appear to occur more frequently than in untreated individuals. Previous work using a dog model has demonstrated bisphosphonate-induced reductions in bone toughness (the inverse of brittleness), yet data are lacking to show this occurs in rodents. The goal of this study was to determine if bisphosphonate-induced alterations in toughness could be quantified in rats. At 26 weeks of age, skeletally mature rats (n = 32 total) were given an injection of either zoledronate (100 μg/kg body weight) or vehicle (0.5 ml saline). Five weeks post-injection, both femora were collected and analyzed for geometry and mechanical properties. To assess the effect of testing rate on the biomechanical outcomes, the left femora were broken at 2 mm/min, while the right femora were broken at 20 mm/min. The results showed a significantly lower energy to failure in zoledronate-treated animals compared to vehicle at the slow testing rate (-15%, p < 0.05) with no difference at the faster rate. While there was not a significant interaction between drug and testing rate for toughness to fracture (p = 0.07), toughness between ultimate stress and fracture was significantly lower with zoledronate only at the slow rate (-40%, p < 0.05). These data document that bisphosphonate-induced reductions in energy absorption and toughness can be quantified in rats yet they are highly dependent on testing rate.
机译：双膦酸盐已被使用多年以抑制骨转换并降低骨折风险。最近，双膦酸盐与非典型股骨骨折有关，这是灾难性的，低创伤，易碎的骨折，其发生率比未经治疗的个体更常见。以前使用狗模型进行的研究已经证明了双膦酸盐诱导的骨骼韧性降低（脆性的倒数），但缺乏数据表明这是在啮齿动物中发生的。这项研究的目的是确定是否可以在大鼠中量化双膦酸酯诱导的韧性变化。在26周龄时，给骨骼成熟的大鼠（共32只）注射唑来膦酸盐（100μg/ kg体重）或赋形剂（0.5 ml生理盐水）。注射后五周，收集两个股骨并分析其几何形状和力学性能。为了评估测试速率对生物力学结果的影响，左股骨以2 mm / min的速度折断，而右股骨以20 mm / min的速度折断。结果表明，在缓慢测试速率下（-15％，p <0.05），与唑来膦酸盐处理动物相比，唑来膦酸盐治疗的动物的衰竭能量明显降低，而更快速率下无差异。虽然药物和断裂韧性测试率之间没有显着的相互作用（p = 0.07），但唑来膦酸盐的最终应力和断裂韧性却显着降低（-40％，p <0.05）。这些数据表明，双膦酸酯诱导的能量吸收和韧性降低可以在大鼠中量化，但它们高度依赖于测试率。

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