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首页> 外文期刊>Journal of orthopaedic research >Late-preconditioning protection is evident in the microcirculation of denervated skeletal muscle.
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Late-preconditioning protection is evident in the microcirculation of denervated skeletal muscle.

机译：失神经骨骼肌的微循环中明显存在后期预处理保护。

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We investigated whether ischemic preconditioning induces microvascular protection in skeletal muscle at the late phase (after 24 hours) when the same muscles are subjected to prolonged warm global ischemia. The cremaster muscle of the male Sprague-Dawley rat underwent vascular isolation and was subjected to 4 hours of ischemia and 60 minutes of reperfusion. Early preconditioning consisted of 45 minutes of ischemia followed by 15 minutes of reperfusion before prolonged ischemia/reperfusion; late preconditioning also consisted of 45 minutes of ischemia but was done 24 hours (24-hour period of reperfusion) before the prolonged ischemia/reperfusion. Arteriole diameters and capillary perfusion were measured with use of intravital microscopy. Four groups were compared: rats that underwent early preconditioning, their controls, rats that underwent late preconditioning, and their controls. Early and late preconditioning significantly attenuated vasospasm and capillary no-reflow compared with the controls for each. Average arteriole diameter was significantly larger in the rats that underwent late preconditioning than in any other rats; it was also significantly larger in the controls for late preconditioning than in those for early preconditioning. We introduce a model of the rat cremaster muscle that has been isolated from its vascular supply as a useful preparation to study the effects of late preconditioning on microcirculation in skeletal muscle. Late preconditioning provided better microvascular protection than did early preconditioning. The mechanism for this preconditioning protection is being investigated because it should provide a means for therapeutic intervention.
机译：我们调查了缺血预处理是否会在晚期肌肉（24小时后）诱导长时间的整体性全局缺血时在骨骼肌中诱导微血管保护。对雄性Sprague-Dawley大鼠的提睾肌进行血管隔离，并进行4小时局部缺血和60分钟再灌注。早期的预处理包括45分钟的局部缺血，然后15分钟的再灌注，然后再进行长时间的局部缺血/再灌注。晚期预处理还包括45分钟的局部缺血，但在长时间的局部缺血/再灌注之前24小时（再灌注24小时）完成。小动脉直径和毛细血管灌注使用活体显微镜测量。比较了四组：进行早期预处理的大鼠，它们的对照，进行晚期预处理的大鼠和它们的对照。与对照相比，早期和晚期预处理显着减弱了血管痉挛和毛细血管无回流。进行后期预处理的大鼠的平均小动脉直径明显大于任何其他大鼠。与早期预处理相比，晚期预处理的对照组也明显更大。我们介绍了大鼠提肌的模型，该模型已从其血管供应中分离出来，作为研究后期预处理对骨骼肌微循环的影响的有用制剂。后期预处理比早期预处理提供了更好的微血管保护。正在研究这种预处理保护的机制，因为它应提供治疗干预的手段。

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