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首页> 外文期刊>Journal of orthopaedic research >Effects of Trypsinization and Mineralization on Intrasynovial Tendon Allograft Healing to Bone
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Effects of Trypsinization and Mineralization on Intrasynovial Tendon Allograft Healing to Bone

机译：胰蛋白酶和矿化作用对同种异体腱鞘内同种异体骨愈合的影响

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摘要

The purpose of the current study was to develop a novel technology to enhance tendon-to-bone interface healing by trypsinizing and mineralizing (TM) an intrasynovial tendon allograft in a rabbit bone tunnel model. Eight rabbit flexor digitorum profundus (FDP) tendons were used to optimize the trypsinization process. An additional 24 FDP tendons were stratified into control and TM groups; in each group, 4 tendons were used for in vitro evaluation of TM and 8 were transplanted into proximal tibial bone tunnels in rabbits. The samples were evaluated histologically and with mechanical testing at postoperative week 8. Maximum failure strength and linear stiffness were not significantly different between the control and TM tendons. A thin fibrous band of scar tissue formed at the graft-to-bone interface in the control group. However, only the TM group showed obvious new bone formation inside the tendon graft and a visible fibrocartilage layer at the bone tunnel entrance. This study is the first to explore effects of TM on the intrasynovial allograft healing to a bone tunnel. TM showed beneficial effects on chondrogenesis, osteogenesis, and integration of the intrasynovial tendon graft, but mechanical strength was the same as the control tendons in this short-term in vivo study. (c) 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:468-474, 2015.
机译：当前研究的目的是开发一种新技术，通过胰兔骨骼隧道模型中的同种异体关节内肌腱的胰蛋白酶消化和矿化（TM）来增强肌腱到骨界面的愈合。八只兔屈指深肌（FDP）肌腱用于优化胰蛋白酶消化过程。将另外的24个FDP肌腱分为对照组和TM组。在每组中，使用4条肌腱进行TM的体外评估，并将8条肌腱移植到兔胫骨近端骨隧道中。术后第8周对样品进行组织学评估和机械测试。对照组和TM肌腱的最大破坏强度和线性刚度没有显着差异。对照组中，在移植物至骨的界面处形成了疤痕组织的细纤维带。但是，只有TM组在腱移植物内部显示出明显的新骨形成，并且在骨隧道入口处可见可见的纤维软骨层。这项研究是第一个探索TM对异体同种异体移植至骨隧道愈合的影响的研究。 TM对软骨形成，成骨和滑膜内腱移植的整合显示出有益的作用，但是在这项短期体内研究中，机械强度与对照肌腱相同。 （c）2015骨科研究学会。由Wiley Periodicals，Inc. J Orthop Res 33：468-474，2015年出版。

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