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首页> 外文期刊>Journal of orthopaedic research >Intermittent pneumatic compression enhances neurovascular ingrowth and tissue proliferation during connective tissue healing: a study in the rat.
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Intermittent pneumatic compression enhances neurovascular ingrowth and tissue proliferation during connective tissue healing: a study in the rat.

机译：大鼠结缔组织愈合期间，间歇性气动加压可增强神经血管向内生长和组织增殖。

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Intermittent pneumatic compression (IPC) is a treatment method to decrease venous stasis and stimulate blood flow. Recently, it was hypothesized that IPC may exert positive effects on tissue healing, a process highly dependent upon adequate circulation. In this study, we investigated the effects of daily 1-h IPC treatment during 2 and 4 weeks post-rat Achilles tendon rupture. The tendons were subjectively and semiquantitatively analyzed for collagen organization, fibroblast density, angiogenesis, and the occurrence of sensory neuropeptides, substance P (SP) and calcitonine gene related peptide (CGRP), as well as for a nerve regeneration marker, growth associated protein 43 (GAP-43). After 2 weeks of treatment, fibroblast density increased by 53% (p = 0.0004), vessel density by 64% (p = 0.022), and the occurrence of SP by 110% (p = 0.047) and CGRP by 47% (p 0.0163) compared to untreated controls. Following 4 weeks of treatment, both the occurrence of sensory neuropeptides and the vessel density remainedsignificantly higher (p < 0.05), whereas fibroblast density returned to normal. However, at 4 weeks the treated tendons displayed a higher degree of organized parallel collagen fibers, a sign of increased maturation. Daily IPC treatment improves neurovascular ingrowth and fibroblast proliferation in the healing tendon and may accelerate the repair process.
机译：间歇性气动压缩（IPC）是一种减少静脉淤滞并刺激血液流动的治疗方法。最近，据推测，IPC可能对组织愈合产生积极影响，这一过程高度依赖于充足的循环。在这项研究中，我们调查了大鼠跟腱断裂后2周和4周每天进行1小时IPC治疗的效果。对腱进行了主观和半定量的胶原组织，成纤维细胞密度，血管生成以及感觉神经肽，P物质（SP）和降钙素基因相关肽（CGRP）的出现以及神经再生标记，生长相关蛋白的分析43 （GAP-43）。治疗2周后，成纤维细胞密度增加53％（p = 0.0004），血管密度增加64％（p = 0.022），SP发生率增加110％（p = 0.047），CGRP发生率增加47％（p 0.0163） ）与未经处理的对照相比。治疗4周后，感觉神经肽的发生和血管密度均显着较高（p <0.05），而成纤维细胞密度恢复正常。但是，在第4周，治疗过的肌腱显示出更高水平的组织化平行胶原纤维，这是成熟度增加的迹象。每日IPC治疗可改善愈合肌腱中的神经血管向内生长和成纤维细胞增殖，并可能加速修复过程。

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