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The role of neuropeptides in the control of regional immunity

机译:神经肽在控制区域免疫中的作用

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摘要

Neuropeptides (NPs) and neurotransmitters are a heterogeneous group of soluble factors that make connections within the neuroendocrine and immune systems. NPs, including substance P (SP), vasoactive intestinal peptide (VIP), α melanocyte-stimulating hormone (α-MSH), and calcitonin gene-related peptide (CGRP), released by nerves that innervate the skin, can modulate the action of innate and adaptive skin immunity as well as the skin cells functions. Their role in several inflammatory skin diseases, such as atopic dermatitis, psoriasis, and vitiligo, and in the isotopic response has been reported.Further progress in understanding the various processes that modulate the interactions of the nervous and the skin immune system is essential to develop effective treatment for inflammatory skin conditions with neurogenic components and for understanding signs and symptoms in the isotopic response and, in general, in the control of global and regional immunity.
机译:神经肽(NPs)和神经递质是可溶性因子的异质性组,它们在神经内分泌和免疫系统内建立联系。由神经支配皮肤的神经释放的NP,包括P物质(SP),血管活性肠肽(VIP),α黑素细胞刺激激素(α-MSH)和降钙素基因相关肽(CGRP),可以调节先天性和适应性皮肤免疫以及皮肤细胞的功能。已经报道了它们在几种炎症性皮肤病中的作用,例如特应性皮炎,牛皮癣和白癜风以及在同位素反应中的作用。理解调节神经和皮肤免疫系统相互作用的各种过程的进一步进展对于发展神经系统至关重要具有神经源性成分的炎症性皮肤病的有效治疗,以及了解同位素反应以及总体而言控制总体和区域免疫的体征和症状的有效方法。

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