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首页> 外文期刊>Clinics in dermatology >Changing paradigms in dermatology: proteomics: a new approach to skin disease.
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Changing paradigms in dermatology: proteomics: a new approach to skin disease.

机译：皮肤病学范式的变化：蛋白质组学：一种治疗皮肤病的新方法。

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Completion of the human genome sequence in 2001 heralded a new age in the understanding of cellular function. By eliminating the need for meticulous nucleotide identification of suspect proteins, a short segment can be identified and, within seconds the remaining sequences culled. Now, investigations can be more specifically targeted at the proteins themselves. Unlike the one gene, one protein approach of years past, proteomics is the field of unraveling the vast network of protein interactions within living cells. Recently, certain dermatologic conditions, such as psoriasis and eczema, have been shown to be the result of immune deregulation. By better understanding the proteins responsible for immune system function, targeted disruptions can alter tissue responses. It is in this vein that proteomics attempts to understand cellular regulation for the eventual therapeutic modification of biologic behavior.
机译：2001年人类基因组序列的完成预示着对细胞功能的认识进入了一个新时代。通过消除对可疑蛋白质进行精细核苷酸鉴定的需求，可以鉴定出短片段，并在几秒钟内剔除其余序列。现在，研究可以更具体地针对蛋白质本身。与过去的一种基因，一种蛋白质研究方法不同，蛋白质组学是揭开活细胞内蛋白质相互作用的广阔网络的领域。近来，已证明某些皮肤病学状况，例如牛皮癣和湿疹是免疫失调的结果。通过更好地了解负责免疫系统功能的蛋白质，靶向破坏可以改变组织反应。正是在这种情况下，蛋白质组学试图了解细胞调控以最终对生物学行为进行治疗修饰。

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