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首页> 外文期刊>Journal of pediatric endocrinology & metabolism: JPEM >Maternal and neonatal urinary iodine excretion and neonatal TSH in relation to use of antiseptic during caesarean section in an iodine sufficient area.
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Maternal and neonatal urinary iodine excretion and neonatal TSH in relation to use of antiseptic during caesarean section in an iodine sufficient area.

机译：孕妇和新生儿尿碘排泄和新生儿TSH与在足够碘量的剖宫产术中使用消毒剂有关。

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摘要

AIM: To evaluate the influence of topical iodine-containing antiseptics on neonatal TSH in full-term infants born by Caesarean section in an iodine sufficient area. POPULATION AND METHODS: Urinary iodide excretion (UIE) was estimated in 86 mothers on the second day after delivery by Caesarean section and their 86 full-term neonates. The mothers were divided into two groups according to the use of antiseptic to prepare Cesarean sections: 42 mothers who were prepared with povidone-iodine (Isosept, Bosnalijek) comprised the study group, and 47 mothers who were prepared with alcoholic solution (Skinsept color, Ecolab) formed the control group. Neonatal TSH was measured in whole blood drawn between day 3 and 5 of life, spotted on filter paper using a sensitive fluorometric assay (Delfia). RESULTS: Maternal and neonatal UIE were significantly higher (p < 0.05) in the study group compared to the control group. No significant difference was found for neonatal TSH. CONCLUSION: Our data suggest that perinatal iodine exposure of full-term neonates who were born by Caesarean section in an iodine sufficient area did not influence neonatal TSH, although median UIE was higher, suggesting optimal iodine intake during pregnancy. Further research is needed to define a critical value of urinary iodine concentrations in full-term neonates in an iodine sufficient area that may lead to the impairment of thyroid function.
机译：目的：评估局部含碘防腐剂对有足够碘量的剖腹产剖腹产足月儿新生儿TSH的影响。人口与方法：剖宫产分娩后第二天，对86名母亲及其86名足月新生儿进行了尿碘排泄（UIE）评估。根据使用防腐剂制备剖宫产的母亲将母亲分为两组：研究组中有42名使用聚维酮碘（Isosept，Bosnalijek）准备的母亲，以及47名使用酒精溶液（肤色， Ecolab）组成了对照组。使用敏感的荧光测定法（Delfia），在生命的第3天到第5天之间抽取的全血中测量新生儿TSH，并将其点在滤纸上。结果：与对照组相比，研究组的孕产妇和新生儿UIE显着更高（p <0.05）。新生儿TSH无明显差异。结论：我们的数据表明，尽管中位数UIE较高，但通过剖腹产在足够的碘区域进行剖腹产出生的足月新生儿的围产期碘摄入量不会影响新生儿的TSH，这表明妊娠期间碘的最佳摄入量。需要进行进一步的研究来确定足月新生儿在碘充足区域中尿碘浓度的临界值，该临界值可能导致甲状腺功能受损。

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