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首页> 外文期刊>Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis >Molecularly imprinted polymer for chlorogenic acid by modified precipitation polymerization and its application to extraction of chlorogenic acid from Eucommia ulmodies leaves
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Molecularly imprinted polymer for chlorogenic acid by modified precipitation polymerization and its application to extraction of chlorogenic acid from Eucommia ulmodies leaves

机译：改良沉淀聚合的绿原酸分子印迹聚合物及其在杜仲叶中提取绿原酸的应用

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摘要

Molecularly imprinted polymers (MIPs) for chlorogenic acid (CGA) were prepared by modified precipitation polymerization using methacrylic acid as a functional monomer, divinylbenzene as a crosslinker and methanol or dimethylsulfoxide as a co-solvent. The prepared MIPs were microspheres with a narrow particle size distribution. Binding experiments and Scatchard analyses revealed that two classes of binding sites, high and low affinity sites, were formed on the MIP. The retention and molecular-recognition properties of the prepared MIP were evaluated using a mixture of water and acetonitrile as a mobile phase in hydrophilic interaction chromatography. With an increase of acetonitrile content, the retention factor of CGA was increased on the MIP. In addition to shape recognition, hydrophilic interactions seem to work for the recognition of CGA on the MIP. The MIP had a specific molecular-recognition ability for CGA, while other related compounds, such as caffeic acid, gallic acid, protocatechuic acid and vanillic acid, could not be recognized by the MIP. Furthermore, the MIP for CGA was successfully applied for extraction of CGA in the leaves of Eucommia ulmodies. (C) 2015 Elsevier B.V. All rights reserved.
机译：通过使用甲基丙烯酸作为功能单体，二乙烯基苯作为交联剂和甲醇或二甲基亚砜作为助溶剂的改性沉淀聚合反应制备用于绿原酸（CGA）的分子印迹聚合物（MIP）。制备的MIP是具有窄粒度分布的微球。结合实验和Scatchard分析表明，在MIP上形成了两类结合位点，即高亲和力和低亲和力。在亲水相互作用色谱中，使用水和乙腈的混合物作为流动相，评估了制备的MIP的保留和分子识别特性。随着乙腈含量的增加，CIP的保留因子在MIP上增加。除形状识别外，亲水相互作用似乎也可用于在MIP上识别CGA。 MIP对CGA具有特定的分子识别能力，而MIP无法识别其他相关化合物，例如咖啡酸，没食子酸，原儿茶酸和香草酸。此外，用于CGA的MIP已成功应用于杜仲叶中CGA的提取。 （C）2015 Elsevier B.V.保留所有权利。

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