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首页> 外文期刊>Clinics in dermatology >Opportunistic localization of skin lesions on vulnerable areas.
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Opportunistic localization of skin lesions on vulnerable areas.

机译：易损部位皮肤病变的机会性定位。

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摘要

Genetic, developmental, and immune defects can make certain anatomic areas of the body more prone than others to harbor skin lesions. Cutaneous areas with skin barrier dysfunction (eg, atopic dermatitis) are the clearest example of vulnerable sites where opportunistic diseases, mainly infections (eg, herpes simplex), can easily occur. Somatic mosaicism, by giving rise to mutated cell clones with a bandlike arrangement, may form tissue segments prone to developing congenital or acquired skin disorders. Cutaneous districts that have been infected by herpes viruses become sites permissive for a subsequent onset of heterogeneous skin disorders, mainly tumors, further infections, and disimmune reactions (Wolf isotopic response). Regional lymphedema, by impairing lymph circulation and consequently the local immune control, favors the location of immunity-related lesions in the involved district. A vast series of skin injuries, such as ionizing or ultraviolet radiation, burns, traumas, and even vaccinations, can render the affected areas vulnerable to subsequent cutaneous disorders. Lack of immune control, ensuing from locally altered neuroimmune interaction, may be the basic defect responsible for the opportunistic location of skin lesions in herpes-infected, lymphedematous, or otherwise damaged areas, together featuring the novel concept of "immunocompromised district."
机译：基因，发育和免疫缺陷会使身体的某些解剖区域比其他部位更容易出现皮肤病变。皮肤屏障功能异常的皮肤区域（例如，特应性皮炎）是容易发生机会性疾病（主要是感染（例如，单纯疱疹））的脆弱部位的最明显例子。体细胞镶嵌术通过产生带状排列的突变细胞克隆，可形成易于发展先天性或获得性皮肤疾病的组织片段。被疱疹病毒感染的皮肤区域成为随后发生异质性皮肤疾病（主要是肿瘤，进一步的感染和免疫反应）的场所（狼同位素反应）。区域淋巴水肿通过削弱淋巴循环，进而影响局部免疫控制，有利于免疫相关病变在受累部位的定位。大量的皮肤伤害，例如电离或紫外线辐射，烧伤，创伤，甚至接种疫苗，可能会使受影响的区域容易遭受随后的皮肤疾病的伤害。由于局部改变的神经免疫相互作用而导致的缺乏免疫控制，可能是导致疱疹感染，淋巴水肿或其他受损区域皮肤病变机会性定位的基本缺陷，同时具有“免疫受损区”的新概念。

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