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首页> 外文期刊>Journal of pharmaceutical sciences. >Effects of glycosylation on the stability of protein pharmaceuticals.
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Effects of glycosylation on the stability of protein pharmaceuticals.

机译：糖基化对蛋白质药物稳定性的影响。

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In recent decades, protein-based therapeutics have substantially expanded the field of molecular pharmacology due to their outstanding potential for the treatment of disease. Unfortunately, protein pharmaceuticals display a series of intrinsic physical and chemical instability problems during their production, purification, storage, and delivery that can adversely impact their final therapeutic efficacies. This has prompted an intense search for generalized strategies to engineer the long-term stability of proteins during their pharmaceutical employment. Due to the well known effect that glycans have in increasing the overall stability of glycoproteins, rational manipulation of the glycosylation parameters through glycoengineering could become a promising approach to improve both the in vitro and in vivo stability of protein pharmaceuticals. The intent of this review is therefore to further the field of protein glycoengineering by increasing the general understanding of the mechanisms by which glycosylation improves the molecular stability of protein pharmaceuticals. This is achieved by presenting a survey of the different instabilities displayed by protein pharmaceuticals, by addressing which of these instabilities can be improved by glycosylation, and by discussing the possible mechanisms by which glycans induce these stabilization effects.
机译：在最近的几十年中，基于蛋白质的疗法由于其在疾病治疗方面的巨大潜力，已大大扩展了分子药理学领域。不幸的是，蛋白质药物在其生产，纯化，储存和运输过程中显示出一系列固有的物理和化学不稳定性问题，可能会对它们的最终治疗效果产生不利影响。这促使人们强烈寻求在蛋白质使用过程中工程化蛋白质长期稳定性的通用策略。由于聚糖具有增加糖蛋白整体稳定性的众所周知的作用，通过糖工程改造糖基化参数的合理操作可能成为改善蛋白质药物体外和体内稳定性的一种有前途的方法。因此，本综述的目的是通过增加对糖基化改善蛋白质药物分子稳定性的机理的一般理解，来进一步推进蛋白质糖工程领域。这是通过对蛋白质药物所显示的不同不稳定性的调查，解决这些不稳定性可以通过糖基化改善以及讨论聚糖诱导这些稳定作用的可能机制来实现的。

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