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首页> 外文期刊>Journal of perinatology: Official journal of the California Perinatal Association >Characteristics of pulmonary hypertension in preterm neonates.
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Characteristics of pulmonary hypertension in preterm neonates.

机译：早产儿肺动脉高压的特征。

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OBJECTIVE: Characteristics of preterm infants who develop pulmonary hypertension (PHT) and their response to inhaled nitric oxide (iNO) are not well described. Our objective was to identify risk factors for PHT in infants <37 weeks gestational age (GA) and to evaluate their response to iNO. STUDY DESIGN: A retrospective chart review was conducted in infants <37 weeks GA born from July/2000 to October/2005 who had an echocardiographic diagnosis of PHT in the first 4 weeks of life. A comparison non-PHT group was generated matched for GA and birth date. Data on prenatal and postnatal characteristics, response to iNO and mortality were collected. RESULTS: Low Apgar scores, preterm premature rupture of membranes, oligohydramnios, pulmonary hypoplasia and sepsis were independently predictive of PHT. Mortality was significantly higher in the PHT group (26.2% versus 4.1%; P<0.0001) compared to the control group. Low birth weight, severe intraventricular hemorrhage and male sex were significantly associated with death in infants with PHT. Thirty-seven percent (23/61) of infants with PHT were treated with inhaled NO. Infants < 29-week GA had poor response to iNO and the response to iNO increased with GA (P<0.02). CONCLUSIONS: Low Apgar scores, oligohydramnios and pulmonary hypoplasia are associated with the development of PHT in premature infants. The percentage of infants responding to iNO increases with advancing GA.
机译：目的：尚不充分描述发生肺动脉高压（PHT）的早产婴儿的特征及其对吸入一氧化氮（iNO）的反应。我们的目标是确定小于37周胎龄（GA）的婴儿PHT的危险因素，并评估其对iNO的反应。研究设计：对出生于出生后头4周的超声心动图诊断为PHT的从2000年7月/ 2000年10月/ 2005年10月出生的GA <37周婴儿进行了回顾性图表回顾。生成了一个与GA和出生日期相匹配的非PHT比较组。收集有关产前和产后特征，对iNO的反应和死亡率的数据。结果：Apgar评分低，胎膜早破，羊水过少，肺发育不全和败血症可独立预测PHT。与对照组相比，PHT组的死亡率显着更高（26.2％对4.1％; P <0.0001）。低出生体重，严重的脑室内出血和男性性别与PHT婴儿的死亡显着相关。 37％（23/61）的PHT婴儿接受了吸入NO的治疗。 GA ＜29周的婴儿对iNO的反应较差，且GA对iNO的反应增加（P <0.02）。结论：Apgar评分低，羊水过少和肺发育不全与早产儿PHT的发展有关。随着GA的增加，对iNO作出反应的婴儿百分比增加。

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