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The cytokine and chemokine network in psoriasis.

机译:牛皮癣的细胞因子和趋化因子网络。

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Creation and maintenance of psoriatic plaques require a multicellular conspiracy by which prepsoriatic skin becomes infiltrated by a variety of immunocytes triggering changes in the behavior of epidermal keratinocytes and endothelial cells. These complex cellular events require coordination in space and time to achieve the mature plaque. Key molecular coordinators dictating behavior and movement of cells within plaques include cytokines as well as chemokines. These mediators of inflammation play fundamentally important roles in the pathophysiology of psoriasis. The purpose of this chapter is to provide an updated review of cytokine and chemokine networks in psoriatic skin lesions.
机译:银屑病斑块的产生和维持需要多细胞阴谋,通过该阴谋,银屑病前皮肤被多种免疫细胞浸润,从而触发表皮角质形成细胞和内皮细胞行为的改变。这些复杂的细胞事件需要空间和时间上的协调才能获得成熟的斑块。决定斑块内细胞行为和运动的关键分子协调员包括细胞因子和趋化因子。这些炎症介质在牛皮癣的病理生理中起着根本性的重要作用。本章的目的是提供有关银屑病皮肤损伤中细胞因子和趋化因子网络的最新综述。

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