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首页> 外文期刊>Clinics in dermatology >Innate immunity and antimicrobial defense systems in psoriasis.
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Innate immunity and antimicrobial defense systems in psoriasis.

机译：牛皮癣的先天免疫和抗菌防御系统。

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Psoriasis is a chronic inflammatory disorder that is mediated by elements of the innate and adaptive immune systems. Its characteristic features in the skin consist of inflammatory changes in both dermis and epidermis, with abnormal keratinocyte differentiation and proliferation. Despite the elucidation of many aspects of psoriasis pathogenesis, some puzzling questions remain to be answered. A major question currently debated is whether psoriasis is a primary abnormality of the epidermal keratinocyte or a reflection of dysregulated bone marrow-derived immunocytes. In this review we will focus on understanding the role of the innate immune system in psoriasis and how this provides a rational solution to address the origin of this multifactorial disease. Innate immunity is nonspecific and genetically based. It protects the body against the constant risk of pathogens through the use of rapidly mobilized defenses that are able to recognize and kill a variety of threats (bacteria, fungi, viruses, etc). The key mechanisms of innate immune responses are the existence of receptors to recognize pathogens and the production of factors that kill pathogens, such as antimicrobial peptides and proteins. Any combination of excessive sensitivity of the innate detection system, or dysregulation of the response system, can manifest both an epidermal phenotype and an abnormal T-cell function. Thus, the multidimensional action of the innate immune system, its triggers, and its recently understood role in T-cell function argue for an important role for innate mechanisms of recognition and response in the pathogenesis of psoriasis.
机译：牛皮癣是一种慢性炎性疾病，由先天性和适应性免疫系统的元素介导。它在皮肤中的特征包括真皮和表皮的炎症变化，以及异常的角质形成细胞分化和增殖。尽管阐明了牛皮癣发病机理的许多方面，但仍有一些令人困惑的问题需要回答。目前争论的一个主要问题是牛皮癣是表皮角质形成细胞的原发性异常还是骨髓来源的免疫细胞失调的反映。在这篇综述中，我们将着重于了解先天免疫系统在牛皮癣中的作用，以及这如何为解决这种多因素疾病的起源提供合理的解决方案。先天免疫是非特异性的并且是基于遗传的。它通过使用能够识别并杀死各种威胁（细菌，真菌，病毒等）的快速动员的防御措施，保护人体免受持续的病原体风险。先天性免疫应答的关键机制是识别病原体的受体的存在和杀灭病原体的因子的产生，例如抗菌肽和蛋白质。先天检测系统灵敏度过高或响应系统失调的任何组合都可能同时表现出表皮表型和异常的T细胞功能。因此，先天免疫系统的多维作用，其触发因素及其最近在T细胞功能中的作用为牛皮癣的发病机理中的先天识别和应答机制提供了重要作用。

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