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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >Distribution of a1(IV) and a3(IV) chains of type IV collagen in lung tumours.
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Distribution of a1(IV) and a3(IV) chains of type IV collagen in lung tumours.

机译：IV型胶原的a1（IV）和a3（IV）链在肺肿瘤中的分布。

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摘要

Tumour invasion is associated with strong remodelling of the extracellular matrix, including the basement membrane (BM). The major structural component of BMs is type IV collagen, which is composed of an association of three a chains. In this study, the distribution of the a1 and a3 chains in both normal and neoplastic lung tissues has been examined by immunohistochemistry, using specific monoclonal antibodies. In normal tissues, the a1(IV) chain was found in all BMs, whereas the a3(IV) chain was only found in alveolar BMs. In 36 lung tumours, the a1(IV) chain was detected in all cases, with irregular positivity around tumour clusters and in the stroma. It was noteworthy that this stromal distribution was particularly associated with the presence of cancer cells, whatever their invasive properties. In contrast, in 22 tumours out of 36, the a3(IV) chain was only found at the interface between invasive tumour clusters and stroma, with a linear and disrupted pattern. These data show a distinctive distribution of type IV collagen chains in lung tumours, with expression of a1(IV) chain and likely neosynthesis of the a3(IV) chain around some invasive tumour clusters. The results suggest the involvement of these BM components in the process of tumour invasion.
机译：肿瘤浸润与细胞外基质，包括基底膜（BM）的强烈重塑有关。 BMs的主要结构成分是IV型胶原蛋白，它由三个a链组成。在这项研究中，已经使用特异性单克隆抗体通过免疫组织化学检查了正常和肿瘤性肺组织中a1和a3链的分布。在正常组织中，在所有BM中都发现了a1（IV）链，而仅在肺泡BM中发现了a3（IV）链。在36个肺肿瘤中，所有病例均检测到a1（IV）链，在肿瘤簇周围和间质中呈不规则阳性。值得注意的是，这种基质分布与癌细胞的存在特别相关，无论它们具有何种侵入特性。相比之下，在36种肿瘤中的22种肿瘤中，仅在浸润性肿瘤簇和基质之间的界面处发现a3（IV）链，且呈线性且破坏的模式。这些数据显示IV型胶原蛋白链在肺肿瘤中有独特的分布，其中a1（IV）链的表达以及可能在某些浸润性肿瘤簇周围新合成a3（IV）链。结果表明这些BM成分参与肿瘤侵袭过程。

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