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首页> 外文期刊>Journal of psychopharmacology >The sub-acute effects of recreational ecstasy (MDMA) use: a controlled study in humans.
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The sub-acute effects of recreational ecstasy (MDMA) use: a controlled study in humans.

机译：休闲摇头丸（MDMA）使用的亚急性效应：对人体的对照研究。

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All previous studies of the sub-acute effects of ecstasy have failed to adequately control for group differences in psychopathology and past and concurrent substance use. The present study was designed to avoid these limitations. At an initial pre-drug baseline, a sample of 38 regular ecstasy users provided full substance histories and completed measures of personality and self-reported psychopathology. We then collected daily subjective measures of mood, cognitive impairment, restless sleep, sexual desire, craving for ecstasy and concomitant use of other substances for the next 9 days. The 20 participants who subsequently opted to take ecstasy during the 9-day assessment period reported modest sub-acute effects of ecstasy on negative mood and subjective cognitive impairment compared to those who did not after controlling for baseline group differences in psychopathology and frequency of ecstasy use. There were no significant sub-acute effects of ecstasy on interest in sexual activity or craving for ecstasy. After further controlling for co-use of alcohol with ecstasy, and the sub-acute effects of ecstasy on sleep, the sub-acute effect on mood remained marginally statistically significant but the subacute effect on cognitive impairment did not. The present findings suggest that the sub-acute effects of ecstasy in regular recreational users are relatively modest and transient but that such genuine effects may have been masked by, perhaps more clinically significant, chronic sequelae of regular ecstasy use in all previous studies of recreational ecstasy users.
机译：以前所有关于摇头丸亚急性作用的研究都未能充分控制心理病理学以及过去和同时使用药物的人群差异。本研究旨在避免这些限制。在最初的药物前基线调查中，有38名经常使用摇头丸的人提供了完整的药物史，并完成了性格和自我报告的心理病理学测量。然后，我们收集了接下来9天的情绪，认知障碍，不安的睡眠，性欲，对摇头丸的渴望和同时使用其他物质的每日主观测量。随后在9天的评估期内选择服用摇头丸的20名参与者报告了摇头丸对负面情绪和主观认知障碍的中等急性发作效果，而那些在控制了心理病理学和摇头丸使用频率的基线组差异之后才没有的人。摇头丸对性活动的兴趣或对摇头丸的渴望没有明显的亚急性影响。在进一步控制酒精与摇头丸的并用以及摇头丸对睡眠的亚急性作用后，对情绪的亚急性作用仍在统计学上具有显着统计学意义，但对认知障碍的亚急性作用却没有统计学意义。本研究结果表明，常规娱乐用户对摇头丸的亚急性作用相对中等和短暂，但在以前的所有娱乐性摇头丸研究中，这种真正的作用可能已被常规摇头丸的慢性临床后遗症掩盖了，也许在临床上更有意义用户。

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