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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >gamma/delta T cells in multiple sclerosis: chemokine and chemokine receptor expression.
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gamma/delta T cells in multiple sclerosis: chemokine and chemokine receptor expression.

机译：多发性硬化中的γ/δT细胞：趋化因子和趋化因子受体的表达。

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摘要

gamma/delta T cells are enriched in multiple sclerosis (MS) brain lesions and have been postulated to contribute to the pathogenesis of the disease. Increased expression of the chemokine receptors CCR5 and CXCR3 on T cells and raised amounts of the chemokines RANTES and IP-10 have been noted in the CSF and brain tissue of MS patients, but the contribution of gamma delta T cells to these increases is unknown. We therefore compared intracellular RANTES and IP-10 production as well as CCR5, CXCR3, and CXCR1 expression by gamma delta T cells derived from the blood and CSF of patients with MS and healthy controls (HC). We observed higher RANTES production by MS gamma delta than by alpha beta T cell lines. Most of the MS as well as the HC gamma delta and alpha beta T cell lines expressed CXCR3, while expression of CXCR1 was low. Interestingly, MS gamma delta T cell lines, compared to lines from HC, expressed lower levels of CCR5. Furthermore, CSF-derived gamma delta T cells had even lower CCR5 expression than blood-derived ones. The higher RANTES production by MS gamma delta T cell lines, together with a lower expression of CCR5, may reflect an autoregulatory loop, caused by an increased production of its ligands (RANTES, MIP-1 alpha, and MIP-1 beta) or due to other pro-inflammatory cytokines. Alternatively, we show that lower CCR5 expression could also reflect the result of repeated in vivo stimulation of gamma delta T cells by autoantigens.
机译：γ/δT细胞富含多发性硬化症（MS）脑损伤，并被认为有助于该病的发病。在MS患者的CSF和脑组织中，已经注意到趋化因子受体CCR5和CXCR3在T细胞上的表达增加以及趋化因子RANTES和IP-10的表达增加，但是伽马三角洲T细胞对这些增加的贡献尚不明确。因此，我们比较了来自MS和健康对照（HC）患者血液和CSF的γ-δT细胞的细胞内RANTES和IP-10产生以及CCR5，CXCR3和CXCR1表达。我们观察到由MSγδ产生的RANTES高于由αβT细胞系产生的。大多数MS以及HCγδ细胞和αβT细胞系均表达CXCR3，而CXCR1的表达则较低。有趣的是，与来自HC的系相比，MSγT细胞系表达的CCR5水平较低。而且，源自CSF的γ-δT细胞比源自血液的细胞具有更低的CCR5表达。 MSγδT细胞系产生的更高的RANTES产生，以及CCR5的更低的表达，可能反映了自身调节环，这是由于其配体（RANTES，MIP-1 alpha和MIP-1 beta）产生的增加或其他促炎细胞因子。或者，我们显示较低的CCR5表达也可能反映出自身抗原对体内γδT细胞反复刺激的结果。

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