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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >The antichromatin antibodies can be useful as a diagnostic tool and disease activity marker of systemic lupus erythematosus in Koreans.
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The antichromatin antibodies can be useful as a diagnostic tool and disease activity marker of systemic lupus erythematosus in Koreans.

机译：抗染色质抗体可用作韩国人系统性红斑狼疮的诊断工具和疾病活动标记。

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摘要

We have investigated the clinical utility of antichromatin antibodies for the diagnosis of SLE and as a marker of disease activity in Korean SLE patients. Blood samples were collected from SLE patients, lupus syndrome patients having only two or three of ACR classification criteria for SLE and normal controls. The level of antichromatin antibody was measured by enzyme linked immunosorbent assay and expressed as arbitrary unit. The antichromatin antibody levels of the SLE and lupus syndrome patients were higher than NC. The antichromatin antibody levels were significant higher in SLE patients with arthritis. A significant correlation was found between the level of antichromatin antibodies and each of anti-dsDNA antibody, leukopenia, complement and SLEDAI. The change of antichromatin antibody levels showed a positive correlation with the change of SLEDAI in serial samples. These data suggest that the antichromatin antibodies appear to be a useful laboratory test that can help in the diagnosis and assessment of SLE.
机译：我们已经研究了抗染色质抗体在SLE诊断中的临床实用性，并作为韩国SLE患者疾病活动的标志物。从SLE患者和狼疮综合征患者中采集血液样本，这些患者仅对SLE和正常对照具有两个或三个ACR分类标准。通过酶联免疫吸附测定法测定抗染色质抗体的水平，并表示为任意单位。 SLE和狼疮综合征患者的抗染色质抗体水平高于NC。 SLE关节炎患者的抗染色质抗体水平显着较高。发现抗染色质抗体的水平与抗dsDNA抗体，白细胞减少症，补体和SLEDAI的水平之间存在显着相关性。一系列样品中抗染色质抗体水平的变化与SLEDAI的变化呈正相关。这些数据表明抗染色质抗体似乎是一种有用的实验室测试，可以帮助诊断和评估SLE。

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