Optimal adaptive control schemes for PHB production in fed-batch fermentation of Ralstonia eutropha

Wu W.; Lai S.-Y.; Jang M.-F.; Chou Y.-S.

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Optimal adaptive control schemes for PHB production in fed-batch fermentation of Ralstonia eutropha

机译：富营养小球藻分批补料发酵生产PHB的最佳自适应控制方案

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A dynamic model for a fed-batch fermentation of Ralstonia eutropha for PHB production is presented. Based on the simplified kinetics, some of kinetic parameters are very sensitive to uncertainties. To develop the robust and feasible feeding strategy, the specific optimal adaptive control strategy is determined by solving the constrained discrete-time optimization algorithm using the genetic algorithm solver in Matlab. The proposed control methods are implemented to the feed flow manipulation with stepwise changes. Through Lyapunov stability analysis, the closed-loop stability regarding the state estimation errors and parametric uncertainties is investigated. Finally, simulations show that the satisfactory output tracking performance is achieved under the two-input control configuration.

机译：提出了富营养性小球藻（Ralstonia eutropha）分批发酵生产PHB的动态模型。基于简化的动力学，某些动力学参数对不确定性非常敏感。为了开发鲁棒而可行的进料策略，通过在Matlab中使用遗传算法求解器求解约束离散时间优化算法，确定具体的最优自适应控制策略。所提出的控制方法可以逐步改变进料流量。通过Lyapunov稳定性分析，研究了关于状态估计误差和参数不确定性的闭环稳定性。最后，仿真表明，在两输入控制配置下，可以获得令人满意的输出跟踪性能。

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来源
《Journal of Process Control》 |2013年第8期|共10页
作者
Wu W.; Lai S.-Y.; Jang M.-F.; Chou Y.-S.;
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正文语种 eng
中图分类控制论、信息论（数学理论）;
关键词
Bioreactors; Dynamic simulation; Optimization; Parameter identification; Stability;

机译：生物反应器;动态模拟;优化;参数辨识;稳定性;

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专利

1. Optimal adaptive control schemes for PHB production in fed-batch fermentation of Ralstonia eutropha [J] . Wu W., Lai S.-Y., Jang M.-F., Journal of Process Control . 2013,第8期

机译：富营养小球藻分批补料发酵生产PHB的最佳自适应控制方案
2. Design considerations in hybrid neural optimization of fed-batch fermentation for PHB production by Ralstonia eutropha. [J] . Patnaik P. R. Food and bioprocess technology . 2010,第2期

机译：富营养性拟南芥生产PHB的分批补料发酵的混合神经优化的设计考虑。
3. Analysis of the effect of flow interruptions on fed-batch fermentation for PHB production by Ralstonia eutropha in finitely dispersed bioreactors [J] . Patnaik PR Chemical Engineering Communications . 2007,第5期

机译：流动中断对有限分散生物反应器中富营养小球藻生产PHB的分批补料发酵的影响分析
4. Multivariable multi-strategy control of a fed-batch fermentation process for the production of poly-/spl beta/-hydroxybutyric acid (PHB) [C] . Pomerleau, Y., Bourque, . 1993

机译：分批补料发酵过程多变量多策略控制，用于生产聚-/ splβ/-羟基丁酸（PHB）
5. ON-LINE, ADAPTIVE, OPTIMAL CONTROL OF A HIGH-DENSITY, FED-BATCH FERMENTATION OF STREPTOMYCES C5. [D] . SCHLASNER, STEVEN MARK. 1987

机译：在线，自适应，最优控制链霉菌C5的高产补料发酵。
6. To Be or Not To Be a Poly(3-Hydroxybutyrate) (PHB) Depolymerase: PhaZd1 (PhaZ6) and PhaZd2 (PhaZ7) of Ralstonia eutropha Highly Active PHB Depolymerases with No Detectable Role in Mobilization of Accumulated PHB [O] . Anna Sznajder, Dieter Jendrossek 2014

机译：是否为聚（3-羟基丁酸）（PHB）解聚酶：富营养小球藻（Ralstonia eutropha）的PhaZd1（PhaZ6）和PhaZd2（PhaZ7）高活性PHB解聚酶在动员积累的PHB中没有可检测的作用
7. Optimal Operation of Fed-Batch Fermentations via Adaptive Control of Overflow Metabolite [O] . Valentinotti S., Srinivasan B., Holmberg U., 2003

机译：通过溢流代谢物的自适应控制优化分批补料发酵操作

Optimal adaptive control schemes for PHB production in fed-batch fermentation of Ralstonia eutropha

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