• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon.
【24h】

Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon.

机译：来自喀麦隆的自身免疫性内分泌疾病患者的糖尿病和甲状腺自身抗体发生率。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Diabetes is a major cause of morbidity and mortality in both industrialized and developing countries. In Africa, there are little data on the prevalence and immunological features of patients with autoimmune endocrine diseases. AIM OF THE STUDY: The present hospital-based study was carried out to evaluate disease-associated autoantibodies in both type 1 diabetes and thyrotoxicosis attending the Central Hospital of Yaoundee in Cameroon. PATIENTS AND METHODS: Samples were collected from a total of 101 subjects, 47 of whom clinically had established type 1 diabetes (mean age 30.1 years +/- 7.6, mean disease duration 3.3 years), 18 had thyrotoxicosis (mean age 32.7 years +/- 7.6, mean disease duration 6.3 years +/- 2.8) and 36 normal subjects (mean age 26 years +/- 4.5). All subjects were tested for diabetes-associated glutamic acid decarboxylase (GAD) and tyrosine phosphatase (IA2) autoantibodies using antigen-specific radioimmunoassay as well as thyroiditis-associated thyroglobulin (Tg) and thyroid peroxidase (TPO) autoantibodies using commercially available kits. RESULTS: Of 47 patients with type 1 diabetes, 16 (34%) had GAD autoantibodies (Abs), 3 (6.4%) had IA2 Abs, and 2 (4.3%) had TPO Abs. Of 18 patients with thyrotoxicosis 4 (22.2%) had GAD Abs, 5 (27.8%) showed IA2 Abs, while 8 patients (44.4%) were TPO Abs positive. No patients in either group had Tg Abs. Among normal subjects, 2 (5.6%) showed GAD Abs, and one of these was also IA2 Abs positive, but none had thyroid autoantibodies. CONCLUSION: Adult-onset type 1 diabetic patients some years post-diagnosis from central Africa show GAD, IA2 or TPO Abs; and surprisingly, patients with thyrotoxicosis had a similar frequency of diabetes-associated autoantibodies. We conclude that, despite a different genetic and environmental background to European populations, islet cell autoimmunity is common in autoimmune endocrine patients in central Africa.
机译：背景：在工业化国家和发展中国家，糖尿病都是发病率和死亡率的主要原因。在非洲，关于自身免疫性内分泌疾病患者的患病率和免疫学特征的资料很少。研究的目的：本项基于医院的研究是在喀麦隆雅温得市中心医院对1型糖尿病和甲状腺毒症中与疾病相关的自身抗体进行评估的。患者与方法：收集了101位受试者的样本，其中47位临床上确诊为1型糖尿病（平均年龄30.1岁+/- 7.6，平均病程3.3年），18位患有甲状腺毒症（平均年龄32.7岁+ / -7.6，平均病程6.3年+/- 2.8）和36名正常受试者（平均年龄26岁+/- 4.5）。使用抗原特异性放射免疫测定法以及所有市售试剂盒对所有受试者的糖尿病相关的谷氨酸脱羧酶（GAD）和酪氨酸磷酸酶（IA2）自身抗体以及甲状腺炎相关的甲状腺球蛋白（Tg）和甲状腺过氧化物酶（TPO）自身抗体进行了测试。结果：47例1型糖尿病患者中，有16例（34％）患有GAD自身抗体（Abs），3例（6.4％）患有IA2抗体，2例（4.3％）患有TPO抗体。在18名甲状腺毒症患者中，有4名（22.2％）患有GAD抗体，其中5名（27.8％）患有IA2抗体，而8名患者（44.4％）的TPO抗体呈阳性。两组中均无患者发生Tg抗体。在正常受试者中，有2名（5.6％）显示GAD抗体，其中之一也是IA2抗体阳性，但没有甲状腺自身抗体。结论：非洲中部地区诊断后数年的成年型1型糖尿病患者显示GAD，IA2或TPO Abs。令人惊讶的是，甲状腺毒症患者的糖尿病相关自身抗体发生频率相似。我们得出结论，尽管欧洲人群的遗传和环境背景不同，但胰岛细胞自身免疫在中部非洲的自身免疫内分泌患者中很常见。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号