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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease.
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Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease.

机译：克罗恩病中FOXP3 + CD4 +调节性T细胞的表征。

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摘要

FOXP3(+)CD4(+) regulatory T cells (T(R)) have emerged as important regulators of immune responses. The aim of our study was to assess the frequency and functional characteristics of FOXP3(+)CD4(+) T(R) in Crohn's disease (CD). We report that FOXP3(+)CD4(+) T(R) cells are expanded in mucosal lymphoid tissues (lamina propria and MLN) but are decreased in the PB in active CD. Patients treated with thiopurines, but not steroids or anti-TNF-alpha inhibitors, have a lower frequency of PB FOXP3(+)CD4(+) T(R) (7.8+/-2.4% vs. 9.9+/-1.8%, p=0.01). FOXP3(+) cells were localized in the lamina propria (LP), muscularis mucosa and serosa and accumulated in granulomas, whereas in MLN they localize in the T cell rich areas. MLN CD4(+)CD25(+) T cells from both CD and normal intestine efficiently suppress the proliferation of effector CD4(+)CD25(-) T cells. T cell activation of MLN in vitro with anti-CD3 plus anti-CD28 Abs enhances the expression of FOXP3, both at the protein and transcriptional level, which is further enhanced by the addition of TGF-beta. In summary, there is an expansion of FOXP3(+)CD4(+) T(R) cells in mucosal lymphoid tissues in CD; they accumulate in areas of active inflammation, including granulomas and retain potent regulatory activity ex vivo.
机译：FOXP3（+）CD4（+）调节性T细胞（T（R））已成为免疫反应的重要调节剂。我们研究的目的是评估在克罗恩病（CD）中FOXP3（+）CD4（+）T（R）的频率和功能特征。我们报告说，FOXP3（+）CD4（+）T（R）细胞在粘膜淋巴组织（固有层和MLN）中扩展，但在活性CD中的PB中降低。使用硫嘌呤而非类固醇或抗TNF-α抑制剂治疗的患者出现PB FOXP3（+）CD4（+）T（R）的频率较低（7.8 +/- 2.4％比9.9 +/- 1.8％， p ＝ 0.01）。 FOXP3（+）细胞位于固有层（LP），肌层粘膜和浆膜中，并在肉芽肿中积累，而在MLN中，它们位于T细胞富集区域。来自CD和正常肠道的MLN CD4（+）CD25（+）T细胞可有效抑制效应CD4（+）CD25（-）T细胞的增殖。体外用抗CD3和抗CD28 Abs激活MLN的T细胞可增强FOXP3在蛋白质和转录水平上的表达，并通过添加TGF-beta进一步增强。总之，在CD的粘膜淋巴组织中存在FOXP3（+）CD4（+）T（R）细胞的扩增。它们积聚在包括肉芽肿在内的活跃炎症区域，并在体外保持有效的调节活性。

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