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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Distinctive homing profile of pathogen-specific activated lymphocytes in human urinary tract infection.
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Distinctive homing profile of pathogen-specific activated lymphocytes in human urinary tract infection.

机译：人尿路感染中病原体特异性活化淋巴细胞的独特归巢谱。

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摘要

In contrast to other mucosal sites, information on migration/homing of lymphocytes activated in the human urinary tract is lacking. The expression of lymphocyte homing receptors (HR) on pathogen-specific antibody-secreting cells (ASC) originating from the urinary tract (patients with pyelonephritis, PN) was compared to that on antigen-specific ASC originating from the intestine (patients with gastroenteritis) or from a parenteral site (tetanus toxoid-immunized volunteers). In the PN group, 61% of ASC expressed the gut HR, alpha(4)beta(7,) 52% the peripheral lymph node HR, L-selectin, and 13% the skin HR, CLA. This homing profile of urinary tract-originating lymphocytes was found to differ from both of the two major vaccination routes, intestinal (less gut-targeting) or parenteral (more gut-targeting, less targeting to parenteral sites). This information on targeting of the immune response may prove useful when developing vaccines against urinary tract infection (UTI).
机译：与其他粘膜部位相反，缺乏关于在人尿道中活化的淋巴细胞的迁移/归巢的信息。比较了源自尿路的病原体特异性抗体分泌细胞（ASC）（肾盂肾炎患者，PN）上淋巴细胞归巢受体（HR）的表达与源自肠道的抗原特异性ASC的表达（胃肠炎患者）的表达进行了比较或非肠道部位（破伤风类毒素免疫的志愿者）。在PN组中，有61％的ASC表达了肠道HR，52％的外周淋巴结HR，L-选择素和13％的皮肤HR，CLA表示了肠道HR，alpha（4）beta（7）。发现这种源自尿路的淋巴细胞的归巢分布与两种主要的疫苗接种途径（肠道（较少肠靶向）或肠胃外（肠道靶向较多，肠胃外靶向较少））均不同。在开发针对尿路感染（UTI）的疫苗时，有关免疫反应靶向的信息可能被证明是有用的。

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