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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice.
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Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice.

机译：血管紧张素II阻断对非肥胖糖尿病小鼠自身免疫性甲状腺炎发展的影响。

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摘要

We evaluated the effects of angiotensin II (Ang II) blockers, losartan, an Ang II receptor blocker, and enalapril, an angiotensin converting enzyme inhibitor, on the development of autoimmune thyroiditis in nonobese diabetic (NOD) mice, an animal model of Hashimoto's thyroiditis (HT). Mice were assigned into three groups, untreated, losartan-treated (30 mg/kg/day), and enalapril-treated (10 mg/kg/day) groups. Thyroiditis was induced by iodide ingestion (experiment 1) or mouse thyroglobulin (Tg) immunization (experiment 2). Both procedures effectively induced thyroiditis. While iodide ingestion failed to induce anti-mouse Tg antibody (TgAb) production, Tg immunization resulted in a significant increase in serum TgAb levels. In both experiments, neither losartan nor enalapril interfered with the development of thyroiditis and TgAb production. These results suggest that Ang II may not be associated with the development of autoimmune thyroiditis in NOD mice. Thus, the Ang II blockade may not have therapeutic potential in HT.
机译：我们评估了血管紧张素II（Ang II）阻滞剂，洛沙坦（Ang II受体阻滞剂）和依那普利（血管紧张素转化酶抑制剂）对非肥胖糖尿病（NOD）小鼠自身免疫性甲状腺炎发展的影响，桥本甲状腺炎的动物模型（H T）。将小鼠分为三组，未治疗，氯沙坦治疗（30 mg / kg /天）和依那普利治疗（10 mg / kg /天）。摄入碘化物（实验1）或小鼠甲状腺球蛋白（Tg）免疫（实验2）可诱发甲状腺炎。两种方法均能有效诱发甲状腺炎。摄入碘化物不能诱导抗小鼠TgAb（TgAb）产生，而Tg免疫则导致血清TgAb水平显着增加。在这两个实验中，氯沙坦和依那普利均未干扰甲状腺炎的发展和TgAb的产生。这些结果表明，Ang II可能与NOD小鼠自身免疫性甲状腺炎的发展无关。因此，Ang II阻断可能对HT没有治疗潜力。

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