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首页> 外文期刊>Journal of psychiatric research >Comprehensive evaluation of cortical structure abnormalities in drug-na?ve, adult patients with obsessive-compulsive disorder: A surface-based morphometry study
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Comprehensive evaluation of cortical structure abnormalities in drug-na?ve, adult patients with obsessive-compulsive disorder: A surface-based morphometry study

机译：初治，成年强迫症成年患者皮质结构异常的综合评估：基于表面的形态学研究

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The study objective was to comprehensively evaluate drug-na?ve, adult patients with Obsessive Compulsive Disorder (OCD) for cortical structure abnormalities in comparison with healthy controls. In this cross-sectional study of case-control design, Magnetic Resonance Imaging (1-mm) was performed in drug-na?ve OCD patients (N = 50) & age- sex-, education- and handedness-matched healthy controls (N = 40). We examined cortical volume, thickness, surface area & local Gyrification Index (LGI) through a completely automated surface-based morphometric analysis using FreeSurfer software. OCD symptoms and insight were assessed using Yale-Brown Obsessive Compulsive Symptom (Y-BOCS) check-list and severity scale. Illness severity was assessed using Clinical Global Impression Severity (CGI-S) Scale. OCD patients had significantly deficient volume, thickness and surface area of right anterior cingulate gyrus (ACG). Right lingual gyrus surface area was found to be significantly decreased in patients. Y-BOCS obsession score had significant negative correlation with left frontal pole volume. Y-BOCS compulsion score had significant negative correlations with right ACG volume and surface area and right lateral orbitofrontal cortex LGI. CGI-Severity score had significant negative correlations with right lingual gyrus volume, thickness and surface area as well as right lateral orbitofrontal area. Y-BOCS insight score showed a significant negative correlation with LGI of left medial OFC and left rostral ACG. Identification of novel deficits involving occipital brain regions and first-time observations of relevant correlations between various illness characteristics and cortical measures in OCD patients supports a network involving anterior cingulate, orbitofrontal and occipital brain regions in the pathogenesis of OCD.
机译：该研究的目的是与健康对照相比，全面评估未成年，成年强迫症（OCD）皮质结构异常的成年患者。在这项病例对照设计的横断面研究中，对未接受过药物的强迫症患者（N = 50）和与年龄，性别，教育程度和习惯相关的健康对照者进行了磁共振成像（1-mm）（ N = 40）。我们通过使用FreeSurfer软件的全自动基于表面的形态分析，检查了皮质的体积，厚度，表面积和局部回旋指数（LGI）。使用耶鲁-布朗强迫症（Y-BOCS）检查表和严重程度量表评估OCD症状和洞察力。使用临床总体印象严重度（CGI-S）量表评估疾病的严重程度。 OCD患者的右前扣带回（ACG）的体积，厚度和表面积明显不足。发现患者右舌回面积明显减少。 Y-BOCS痴迷评分与左额叶极容积显着负相关。 Y-BOCS强迫评分与右侧ACG体积和表面积以及右侧外侧额叶皮层LGI呈显着负相关。 CGI严重度评分与右舌回体积，厚度和表面积以及右外侧眶额区显着负相关。 Y-BOCS洞察力评分显示与左内侧OFC和左延髓ACG的LGI显着负相关。鉴定涉及枕脑区域的新缺陷以及对强迫症患者各种疾病特征与皮质测量之间的相关性的首次观察支持了一个网络，涉及强迫症发病机制中的前扣带，眶额和枕脑区域。

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