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首页> 外文期刊>Journal of psychiatry & neuroscience: JPN >Sad mood induction has an opposite effect on amygdala response to emotional stimuli in euthymic patients with bipolar disorder and healthy controls
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Sad mood induction has an opposite effect on amygdala response to emotional stimuli in euthymic patients with bipolar disorder and healthy controls

机译：悲伤的情绪诱导对患有双相情感障碍和健康对照的幸福感患者的杏仁核对情绪刺激的反应具有相反的作用

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Background: Aberrant amygdala reactivity to affective stimuli represents a candidate factor predisposing patients with bipolar disorder (BD) to relapse, but it is unclear to what extent amygdala reactivity is state-dependent. We evaluated the modulatory influence of mood on amygdala reactivity and functional connectivity in patients with remitted BD and healthy controls. Methods: Amygdala response to sad versus neutral faces was investigated using fMRI during periods of normal and sad mood induced by autobiographical scripts. We assessed the functional connectivity of the amygdala to characterize the influence of mood state on the network responsible for the amygdala response. Results: We included 20 patients with remitted BD and 20 controls in our study. The sad and normal mood exerted opposite effects on the amygdala response to emotional faces in patients compared with controls (F-1.38 = 5.85, p = 0.020). Sad mood amplified the amygdala response to sad facial stimuli in controls but attenuated the amygdala response in patients. The groups differed in functional connectivity between the amygdala and the inferior prefrontal gyrus (p <= 0.05, family-wise error-corrected) of ventrolateral prefrontal cortex (vlPFC) corresponding to Brodmann area 47. The sad mood challenge increased connectivity during the period of processing sad faces in patients but decreased connectivity in controls. Limitations: Limitations to our study included long-term medication use in the patient group and the fact that we mapped only depressive (not manic) reactivity. Conclusion: Our results support the role of the amygdala-vlPFC as the system of dysfunctional contextual affective processing in patients with BD. Opposite amygdala reactivity unmasked by the mood challenge paradigm could represent a trait marker of altered mood regulation in patients with BD.
机译：背景：杏仁核对情感刺激的反应性是使躁郁症（BD）患者复发的诱因，但目前尚不清楚杏仁核反应性在多大程度上取决于状态。我们评估了情绪对BD缓解患者和健康对照者杏仁核反应性和功能连接性的调节作用。方法：在自传体脚本诱发的正常和悲伤情绪期间，使用fMRI研究了杏仁核对悲伤和中性面孔的反应。我们评估了杏仁核的功能连接性，以表征情绪状态对负责杏仁核反应的网络的影响。结果：我们的研究包括20例BD缓解患者和20例对照。与对照组相比，悲伤和正常的情绪对杏仁核对情绪面孔的反应产生相反的影响（F-1.38 = 5.85，p = 0.020）。悲伤的情绪在对照组中放大了杏仁核对面部悲伤刺激的反应，但减弱了患者的杏仁核反应。各组在杏仁核和对应于Brodmann区域47的腹外侧前额叶皮层（vlPFC）之间的杏仁核和下额叶前回（p <= 0.05，按家庭方式进行了误差校正）之间的功能连接性有所不同。处理患者的悲伤面孔，但控件的连通性降低。局限性：我们研究的局限性包括在患者组中长期使用药物，以及我们仅绘制了抑郁（而非躁狂）反应性这一事实。结论：我们的结果支持杏仁核-vlPFC作为BD患者功能性情境情感加工系统的作用。情绪挑战范例所掩盖的相反杏仁核反应性可能是BD患者情绪调节改变的特征标记。

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