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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Decreased circulating iNKT cell numbers in refractory coeliac disease.
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Decreased circulating iNKT cell numbers in refractory coeliac disease.

机译：难治性腹腔疾病中循环iNKT细胞数量减少。

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INTRODUCTION: A small proportion of coeliac disease (CD) patients become refractory (RCD) to a gluten-free diet (GFD) showing uncontrolled immune-mediated enteropathy. Some of these patients exhibit a high risk to develop enteropathy-associated T-cell lymphoma (EATL). AIM: The aim of the study was to find whether a lack of circulating homeostatic T cells, such as Treg, Tgammadelta(+) or iNKT cells would be associated with the development of RCD or EATL. PATIENTS AND METHODS: We investigated in a total of 137 CD patients [28 untreated, 80 responsive to GFD and 29 RCD (14 type I and 15 type II)] and 73 age-matched healthy volunteers the frequency of Treg, Tgammadelta(+) and iNKT lymphocytes by flow cytometric analysis of peripheral blood. RESULTS: Circulating Tgammadelta(+) cell and Treg frequencies in RCD were comparable to those in healthy controls. However, RCD patients had significantly reduced numbers of circulating iNKT cells, as compared to age-matched patients responding to a GFD. This reduction was similar in RCD patients with and without aberrant intraepithelial lymphocytes and in patients with EATL. Circulating iNKT cell numbers were not reduced in untreated coeliac patients. GFD treated patients had a significantly increased proportion of CD4(+) iNKT cells. CONCLUSION: Follow-up studies are necessary to determine whether CD4(+) iNKT cells control the immune response against gluten and their absence contributes to the progression to RCD and EATL.
机译：简介：一小部分的腹腔疾病（CD）患者对无麸质饮食（GFD）表现出难治性（RCD），表现出不受控制的免疫介导的肠病。这些患者中有些表现出发展为肠病相关性T细胞淋巴瘤（EATL）的高风险。目的：该研究的目的是发现缺乏循环稳态T细胞，例如Treg，Tgammadelta（+）或iNKT细胞是否与RCD或EATL的发展有关。患者和方法：我们调查了总共137名CD患者[28名未经治疗，80名对GFD有反应和29名RCD（14名I型和15名II型）]和73名年龄相匹配的健康志愿者的Treg，Tgammadelta（+）频率流式细胞仪分析外周血和iNKT淋巴细胞。结果：RCD中的循环Tgammadelta（+）细胞和Treg频率与健康对照者相当。但是，与年龄相匹配的GFD患者相比，RCD患者的循环iNKT细胞数量明显减少。在患有和不患有上皮内淋巴细胞异常的RCD患者以及患有EATL的患者中，这种减少相似。未经治疗的腹腔疾病患者的循环iNKT细胞数量并未减少。 GFD治疗的患者的CD4（+）iNKT细胞比例显着增加。结论：后续研究是必要的，以确定CD4（+）iNKT细胞是否控制针对麸质的免疫反应，而它们的缺失会促进RCD和EATL的进展。

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