Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases

Zhou Zejun; Ding Miao; Huang Lei; Gilkeson Gary; Lang Ren; Jiang Wei

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Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases

机译：肠道巨噬细胞中Toll样受体介导的免疫反应;对粘膜免疫和自身免疫性疾病的影响

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Monocytes are precursors of macrophages and key players during inflammation and pathogen challenge in the periphery, whereas intestinal resident macrophages act as innate effector cells to engulf and clear bacteria, secrete cytokines, and maintain intestinal immunity and homeostasis. However, perturbation of toll-like receptor signaling pathway in intestinal macrophages has been associated with tolerance breakdown in autoimmune diseases. In the present review, we have summarized and discussed the role of toll-like receptor signals in human intestinal macrophages, and the role of human intestinal macrophages in keeping human intestinal immunity, homeostasis, and autoimmune diseases. (C) 2016 Elsevier Inc. All rights reserved.

机译：单核细胞是巨噬细胞的前体，是炎症和周围病原体攻击过程中的关键角色，而肠道常驻巨噬细胞则作为先天的效应细胞，吞噬和清除细菌，分泌细胞因子，并维持肠道免疫力和体内稳态。然而，肠道巨噬细胞中toll样受体信号通路的扰动与自身免疫性疾病的耐受性下降有关。在本综述中，我们总结并讨论了Toll样受体信号在人肠巨噬细胞中的作用，以及人肠巨噬细胞在保持人肠道免疫，体内平衡和自身免疫性疾病中的作用。（C）2016 Elsevier Inc.保留所有权利。

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《Clinical immunology: The official journal of the Clinical Immunology Society》 |2016年第null期|共6页
作者
Zhou Zejun; Ding Miao; Huang Lei; Gilkeson Gary; Lang Ren; Jiang Wei;
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正文语种 eng
中图分类医学免疫学;
关键词
Macrophages; Monocytes; Autoimmune disease; Intestine;

机译：巨噬细胞;单核细胞;自身免疫性疾病;肠;

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1. Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases [J] . Zhou Zejun, Ding Miao, Huang Lei, Clinical immunology: The official journal of the Clinical Immunology Society . 2016,第Null期

机译：肠道巨噬细胞中Toll样受体介导的免疫反应;对粘膜免疫和自身免疫性疾病的影响
2. Intestinal macrophages in mucosal immunity and their role in systemic lupus erythematosus disease [J] . Pan F., Tang W., Zhou Z., Lupus . 2018,第12期

机译：粘膜免疫肠道巨噬细胞及其在全身性红斑狼疮中的作用
3. Intestinal Microflora and Homeostasis of the Mucosal Immune Response: Implications for Probiotic Bacteria? [J] . Stephanie Blum, Eduardo J. Schiffrin Current issues in intestinal microbiology . 2003,第2期

机译：肠道菌群和粘膜免疫反应的体内稳态：对益生菌的影响？
4. Mucosal immunity, intestinal microflora and inflammatory bowel disease [C] . H. TLASKALOVA-HOGENOVA, R. STEPANKOVA, D. SOKOL, Falk Symposium . 2004

机译：粘膜免疫，肠道微生物，炎症肠病
5. Modulating the immune response: Part I: Biochemical activation of PAD4 and function in autoimmune disease Part II: Phage display tools for the study of protein-protein interactions in the immune system [D] . Rohrbach, Amanda S. 2012

机译：调节免疫应答：第一部分：PAD4的生化激活及其在自身免疫性疾病中的功能第二部分：用于研究免疫系统中蛋白质相互作用的噬菌体展示工具
6. Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases [O] . Zejun Zhou, Miao Ding, Lei Huang, -1

机译：Toll样受体介导的肠道巨噬细胞免疫反应；对粘膜免疫和自身免疫性疾病的影响
7. Prospects for bovine production disease control based on the mucosal immunity and innate immune system : From the respiratory mucosal defense and alveolar macrophage dynamics [O] . S. Ishikawa, H. Ohtsuka 2017

机译：基于粘膜免疫和先天免疫系统的牛生产疾病控制前景：来自呼吸粘膜防御和肺泡巨噬细胞动态

Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases

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