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首页> 外文期刊>Journal of Reproductive Immunology >Pregnancy and multiple sclerosis: Feto-maternal immune cross talk and its implications for disease activity
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Pregnancy and multiple sclerosis: Feto-maternal immune cross talk and its implications for disease activity

机译：妊娠和多发性硬化症：胎儿与母亲的免疫串扰及其对疾病活动的影响

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Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system of presumed autoimmune origin. Intriguingly, pregnancy in female MS patients is associated with a substantial decrease in relapse rate. However, post-partum the relapse rate increases in a rebounding fashion above the rate seen before pregnancy. Wide gaps remain in our understanding of the biological mechanisms underlying these pregnancy-related effects in MS patients. To date, most attempts to explain MS disease amelioration during pregnancy have focused on levels of circulating hormones with immunomodulatory properties such as estrogens and global shifts in systemic maternal immune cell composition. However, recent advances in our understanding of feto-maternal tolerance have provided evidence that fetal antigens directly interact with the maternal immune system. This results in specific immunomodulation such as fetal-antigen-dependent induction of regulatory T cells. Thus, the "shaping" of maternal immune responses by fetal antigens may represent an endogenous pathway by which antigen-specific immunomodulation might also contribute to reinstalling tolerance to autoantigens in MS. Reproductive immunology therefore has great potential to provide insights into MS immunopathogenesis and highlight novel avenues for treatment of MS and other autoimmune diseases. ? 2012.
机译：多发性硬化症（MS）是推测为自身免疫性起源的中枢神经系统的炎症性脱髓鞘疾病。有趣的是，女性MS患者的怀孕与复发率的大幅降低有关。但是，产后复发率以反弹的方式增加，高于怀孕前的水平。我们对MS患者这些与妊娠相关的影响的生物学机制的理解仍然存在很大差距。迄今为止，大多数解释妊娠期MS疾病改善的尝试都集中在具有免疫调节特性的循环激素水平上，例如雌激素和全身性母体免疫细胞组成的整体变化。但是，我们对胎儿-母亲耐受性的了解的最新进展提供了证据，表明胎儿抗原直接与母亲免疫系统相互作用。这导致特异性免疫调节，例如调节性T细胞的胎儿抗原依赖性诱导。因此，胎儿抗原对母体免疫反应的“塑形”可能代表了一种内源性途径，通过该途径，抗原特异性免疫调节也可能有助于重新建立对MS自身抗原的耐受性。因此，生殖免疫学具有巨大潜力，可为MS免疫发病机制提供见解，并为MS和其他自身免疫性疾病的治疗提供新途径。 ？ 2012。

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