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首页> 外文期刊>Journal of Reproductive Immunology >Prenatal maternal factors in the development of cognitive impairments in the offspring
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Prenatal maternal factors in the development of cognitive impairments in the offspring

机译：产后母体因素影响后代认知障碍的发展

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Different environmental factors acting during sensitive prenatal periods can have a negative impact on neurodevelopment and predispose the individual to the development of various psychiatric conditions that often share cognitive impairments as a common component. As cognitive symptoms remain one of the most challenging and resistant aspects of mental illness to be treated pharmacologically, it is important to investigate the mechanisms underlying such cognitive deficits, with particular focus on the impact of early life adverse events that predispose the individual to mental disorders. Multiple clinical studies have, in fact, repeatedly confirmed that prenatal maternal factors, such as infection, stress or malnutrition, are pivotal in shaping behavioral and cognitive functions of the offspring, and in the past decade many preclinical studies have investigated this hypothesis.
机译：在敏感的产前时期起作用的不同环境因素可能会对神经发育产生负面影响，并使个人容易患上通常共享认知障碍作为共同组成部分的各种精神疾病。由于认知症状仍然是需要用药理学治疗的精神疾病最具挑战性和抵抗力的方面之一，因此重要的是研究这种认知缺陷的潜在机制，尤其要关注使个体易患精神疾病的早期不良事件的影响。实际上，多项临床研究已经反复证实，产前母体因素（如感染，压力或营养不良）对于塑造后代的行为和认知功能至关重要，并且在过去的十年中，许多临床前研究已经研究了这一假说。

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