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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >KIR2DS4 allelic variants: Differential effects on in'utero and intrapartum HIV-1 mother-to-child transmission
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KIR2DS4 allelic variants: Differential effects on in'utero and intrapartum HIV-1 mother-to-child transmission

机译：KIR2DS4等位基因变体：对子宫内和分娩期间HIV-1母婴传播的差异影响

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Abstract KIR2DS4 is the only activating gene within the A haplotype, and alleles of KIR2DS4 can encode either functional (KIR2DS4-f) or non-functional (KIR2DS4-V) variants. To establish the role of KIR2DS4 in the context of HIV-1 mother-to-child transmission, we KIR genotyped 145 HIV-1 non-transmitting mothers (NT) and their exposed uninfected infants (EU), and 72 HIV-1 transmitting mothers (TR) and their infected infants [intrapartum (IP), in utero (IU) or 1U2 (an lU-enriched infected group)]. The frequency of KIR2DS4-V was significantly higher in IU2 infants compared to EU infants (P = 0.022, OR = 2.88); this association was more significant amongst AA haplotypes (P = 0.004, OR = 18.4). Possession of KIR2DS4-f in the mother with absence in the infant (M+l- discordance) was associated with a higher risk of IP transmission (P = 0.005, OR = 3.84); whilst in M-1 + discordance, infant possession of KIR2DS4-V was associated with increased risk of IU acquisition (P = 0.002; OR = 6.40). This study highlights the importance of KIR2DS4 in HIV-1 transmission/acquisition.
机译：摘要KIR2DS4是A单倍型中唯一的激活基因，KIR2DS4的等位基因可以编码功能性（KIR2DS4-f）或非功能性（KIR2DS4-V）变体。为了确定KIR2DS4在HIV-1母婴传播方面的作用，我们对145个HIV-1非传播母亲（NT）及其暴露的未感染婴儿（EU）和72个HIV-1传播母亲进行了基因分型（TR）及其感染的婴儿[产前（IP），在子宫内（IU）或1U2（富含lU的感染组）]。 IU2婴儿中的KIR2DS4-V的频率明显高于EU婴儿（P = 0.022，OR = 2.88）。在AA单倍型中，这种关联更为显着（P = 0.004，OR = 18.4）。母亲拥有KIR2DS4-f而婴儿不在（M + 1-不一致）与IP传播的风险较高相关（P = 0.005，OR = 3.84）。而在M-1 +不和谐中，婴儿拥有KIR2DS4-V与IU捕获风险增加相关（P = 0.002; OR = 6.40）。这项研究强调了KIR2DS4在HIV-1传播/获取中的重要性。

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