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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Phagocyte-derived S100 proteins in autoinflammation: putative role in pathogenesis and usefulness as biomarkers.
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Phagocyte-derived S100 proteins in autoinflammation: putative role in pathogenesis and usefulness as biomarkers.

机译：吞噬细胞衍生的S100蛋白在自身炎症中的作用：在发病机理中的假定作用以及作为生物标记物的有用性。

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摘要

The cytoplasmic S100 proteins derived from cells of myeloid origin are promising new markers of (auto-)inflammation. S100A8/A9 and S100A12 are released from monocytes and granulocytes during activation of the innate immune system. Tissue and serum concentrations correlate to disease activity, both during local and systemic inflammation. In autoinflammatory diseases such as Familial Mediterranean Fever (FMF) and Systemic onset Juvenile Idiopathic Arthritis (SJIA), a dysregulation of alternative secretory pathways may be involved in pathogenesis and lead to hypersecretion of S100 proteins. Since autoinflammatory diseases can be difficult to diagnose, phagocyte-derived S100 proteins are valid tools in the diagnosis of autoinflammatory diseases. In addition, they may help achieve a better understanding of the pathophysiology of autoinflammatory disorders including SJIA and FMF, and even provide novel therapeutic targets in the future.
机译：来源于髓样细胞的细胞质S100蛋白有望成为（自体）炎症的新标志。 S100A8 / A9和S100A12在先天免疫系统激活期间从单核细胞和粒细胞释放。在局部和全身炎症期间，组织和血清浓度与疾病活动相关。在诸如家族性地中海热（FMF）和全身发作的青少年特发性关节炎（SJIA）等自身炎症性疾病中，其他分泌途径的失调可能与发病机理有关，并导致S100蛋白的过度分泌。由于自身炎症性疾病难以诊断，因此吞噬细胞衍生的S100蛋白是诊断自身炎症性疾病的有效工具。此外，它们可能有助于更好地了解包括SJIA和FMF在内的自身炎症性疾病的病理生理，甚至在将来提供新的治疗靶标。

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