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首页> 外文期刊>Biopolymers: Original Research on Biomolecules and Biomolecular Assemblies >Synthesis and characterization of the biodegradable polycaprolactone-graft-chitosan amphiphilic copolymers
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Synthesis and characterization of the biodegradable polycaprolactone-graft-chitosan amphiphilic copolymers

机译：可生物降解的聚己内酯-接枝-壳聚糖两亲共聚物的合成与表征

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摘要

A novel synthetic approach to biodegradable amphiphilic copolymers based on poly (epsilon-caprolactone) (PCL) and chitosan was presented, and the prepared copolymers were used to prepare nanoparticles successfully. The PCL-graft-chitosan copolymers were synthesized by coupling the hydroxyl end-groups on preformed PCL chains and the amino groups present on 6-O-triphenylmethyl chitosan and by removing the protective 6-O-triphenylmethyl groups in acidic aqueous solution. The PCL content in the copolymers can be controlled in the range of 10-90 wt %. The graft copolymers were thoroughly characterized by H-1 NAM, C-13 NMR, FT-IR and DSC. The nanoparticles made from the graft copolymers were investigated by H-1 NMR, DLS, AFM and SEM measurements. It was found that the copolymers could form spherical or elliptic nanoparticles it? water. The amount of available primary amines on the surface of the prepared nanoparticles was evaluated by ninhydrin assail, and it can be controlled by the grafting degree of PCL. (c) 2006 Wiley Periodicals, Inc.
机译：提出了一种基于聚ε-己内酯（PCL）和壳聚糖的生物可降解两亲共聚物的合成方法，并将其用于成功制备纳米粒子。 PCL-接枝-壳聚糖共聚物是通过将预制的PCL链上的羟基端基与6-O-三苯基甲基壳聚糖上存在的氨基偶联，并除去酸性水溶液中的6-O-三苯基甲基保护基而合成的。共聚物中的PCL含量可以控制在10-90wt％的范围内。通过H-1 NAM，C-13 NMR，FT-IR和DSC对接枝共聚物进行了全面表征。通过H-1 NMR，DLS，AFM和SEM测量研究了由接枝共聚物制成的纳米颗粒。发现该共聚物能形成球形或椭圆形的纳米颗粒吗？水。制备的纳米颗粒表面上可用的伯胺的量通过茚三酮攻击来评估，并且可以通过PCL的接枝度来控制。 （c）2006年Wiley Periodicals，Inc.

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