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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Increased CD4~+CD25~+FoxP3~+ regulatory T cells in the blood of nonresponders after standard hepatitis B surface antigen vaccine immunization
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Increased CD4~+CD25~+FoxP3~+ regulatory T cells in the blood of nonresponders after standard hepatitis B surface antigen vaccine immunization

机译：标准乙型肝炎表面抗原疫苗免疫后无反应者血液中CD4〜+ CD25〜+ FoxP3〜+调节性T细胞增加

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To the Editor:HBV infection is a major public health problem. For nearly two decades, vaccines against HBV have been administered routinely and the antibodies they elicit are clearly effective in preventing HBV infections. However, about 5% of healthy vaccine recipients fail to produce protective levels of antibodies (defined as an antibody level <10 IU/l) to hepatitis B surface antigen vaccine after standard immunization. This phenomenon has been observed in all surveys of vaccine effectiveness, irrespective of the HBsAg vaccine employed, and its cause remains largely unknown. Recent evidence showed that CD4~+CD25~+FoxP3~+ regulatory T cells (Tregs) not only could suppress the activation and proliferation of other CD4~+ and CD8~+ T cells, but also could notably suppress B cell Ig production. We tested the hypothesis whether up-regulation of Tregs was involved in nonresponsiveness to HBsAg vaccines.
机译：致编者：乙肝病毒感染是主要的公共卫生问题。近二十年来，常规已接种了抗HBV疫苗，它们引起的抗体显然可有效预防HBV感染。但是，大约5％的健康疫苗接种者在标准免疫后无法产生针对乙肝表面抗原疫苗的保护水平的抗体（定义为抗体水平<10 IU / l）。无论使用何种HBsAg疫苗，在所有疫苗有效性调查中均已观察到这种现象，并且其原因仍然未知。最近的证据表明，CD4〜+ CD25〜+ FoxP3〜+调节性T细胞（Tregs）不仅可以抑制其他CD4〜+和CD8〜+ T细胞的活化和增殖，而且可以显着抑制B细胞Ig的产生。我们检验了以下假设：Tregs的上调是否参与了对HBsAg疫苗的无反应性。

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