A Novel Once-Daily Fixed-Dose Combination of Memantine Extended Release and Donepezil for the Treatment of Moderate to Severe Alzheimer's Disease: Two Phase I Studies in Healthy Volunteers

Boinpally Ramesh; Chen Laishun; Zukin Stephen R.; McClure Natalie; Hofbauer Robert K.; Periclou Antonia

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A Novel Once-Daily Fixed-Dose Combination of Memantine Extended Release and Donepezil for the Treatment of Moderate to Severe Alzheimer's Disease: Two Phase I Studies in Healthy Volunteers

机译：美金刚缓释和多奈哌齐的新型每日一次固定剂量组合治疗中度至重度阿尔茨海默氏病：健康志愿者的两项I期研究

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Background Combining two standard-of-care medications for Alzheimer's disease (AD) into a single once-daily dosage unit may improve treatment adherence, facilitate drug administration, and reduce caregiver burden. A new fixed-dose combination (FDC) capsule containing 28 mg memantine extended release (ER) and 10 mg donepezil was evaluated for bioequivalence with co-administered commercially available memantine ER and donepezil, and for bioavailability with regard to food intake.

机译：背景技术将两种用于阿尔茨海默氏病（AD）的护理标准药物合并到一个单一的每日一次剂量单位中，可以改善治疗依从性，促进药物管理并减轻护理人员的负担。评价了含有28 mg美金刚缓释（ER）和10 mg多奈哌齐的新固定剂量组合（FDC）胶囊与市售美金刚ER和多奈哌齐的共同生物等效性，以及食物摄入的生物利用度。

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《Clinical drug investigation》 |2015年第7期|共9页
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Boinpally Ramesh; Chen Laishun; Zukin Stephen R.; McClure Natalie; Hofbauer Robert K.; Periclou Antonia;
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正文语种 eng
中图分类药学;
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1. A Novel Once-Daily Fixed-Dose Combination of Memantine Extended Release and Donepezil for the Treatment of Moderate to Severe Alzheimer's Disease: Two Phase I Studies in Healthy Volunteers [J] . Boinpally Ramesh, Chen Laishun, Zukin Stephen R., Clinical drug investigation . 2015,第7期

机译：美金刚缓释和多奈哌齐的新型每日一次固定剂量组合治疗中度至重度阿尔茨海默氏病：健康志愿者的两项I期研究
2. A fixed-dose combination of memantine extended-release and donepezil in the treatment of moderate-to-severe Alzheimer’s disease [J] . William James Deardorff, George T Grossberg Drug Design, Development and Therapy . 2016,第5期

机译：美金刚缓释和多奈哌齐的固定剂量联合治疗中重度阿尔茨海默氏病
3. Pharmacokinetics of extended-release versus conventional tramadol/acetaminophen fixed-dose combination tablets: an open-label, 2-treatment, multiple-dose, randomized-sequence crossover study in healthy korean male volunteers. [J] . Yi S, Chung YJ, Kim TE, Clinical therapeutics . 2011,第6期

机译：延长释放与常规曲马多/对乙酰氨基酚固定剂量组合片剂的药代动力学：在健康的韩国男性志愿者中进行的开放标签，2治疗，多剂量，随机序列交叉研究。
4. Pharmacokinetic Studies with a Mucoadhesive Multilayer Extended-Release Tablet Formulation ofLevodopa-Carbidopa in Healthy Volunteers [C] . Peyman Moslemy, Bennett Carter, Nicholas Cardoso, Controlled Release Society Annual Meeting and Exposition . 2007

机译：左旋多巴-卡比多巴的粘膜粘附多层延长释放片制剂在健康志愿者中的药代动力学研究。
5. Investigating Nutritional Status in Moderate to Severe Alzheimer's Disease Patients Enrolled in a Randomized Controlled Trial with Nabilone [D] . Sherman, Chelsea. 2018

机译：研究中度至重度阿尔茨海默氏病患者的营养状况，该患者参加了纳比隆的随机对照试验
6. A Novel Once-Daily Fixed-Dose Combination of Memantine Extended Release and Donepezil for the Treatment of Moderate to Severe Alzheimer’s Disease: Two Phase I Studies in Healthy Volunteers [O] . Ramesh Boinpally, Laishun Chen, Stephen R. Zukin, -1

机译：美金刚缓释和多奈哌齐的每日一次固定剂量组合治疗中度至重度阿尔茨海默氏病的新方法：健康志愿者的两项I期研究
7. A Novel Once-Daily Fixed-Dose Combination of Memantine Extended Release and Donepezil for the Treatment of Moderate to Severe Alzheimer’s Disease: Two Phase I Studies in Healthy Volunteers [O] . 2015

机译：美金刚缓释和多奈哌齐的每日一次固定剂量组合治疗中度至重度阿尔茨海默病的新方法：健康志愿者的两项I期研究

A Novel Once-Daily Fixed-Dose Combination of Memantine Extended Release and Donepezil for the Treatment of Moderate to Severe Alzheimer's Disease: Two Phase I Studies in Healthy Volunteers

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